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Contents of BDNF, miR-30a-5p AND miR-122 during Alcohol Withdrawal Syndrome

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Abstract

Some brain-derived neurotrophic factor (BDNF)-targeted miRNAs such as miR-30a-5p may be associated with alcohol addiction; however, their relationship with alcohol withdrawal syndrome (AWS) is not described. We aimed to measure serum BDNF concentration and relative content of miR-30a-5p over the course of alcohol abstinence and compare results with the clinics of AWS. Apart from that, we studied the serum relative content of miR-122, a miRNA that does not target BDNF but is associated with alcohol use disorder. Serum BDNF concentration increases over the course of alcohol abstinence. In contrast, the relative content of miR-122, but not miR-30a-5p, decreased. Moreover, miR-122 (but not miR-30a-5p) negatively correlated with serum BDNF concentrations in the course of AWS. The relative content of miR-122 negatively correlated with depression and anxiety levels on day 8 of abstinence. According to multiple regression analysis, the severity of craving for alcohol and cognitive disturbances may be predictors of serum BDNF concentration on day 21 of abstinence, and vice versa. Thus, serum BDNF concentration and relative content of miR-122 are associated with some aspects of AWS clinical manifestations and may dynamically reflect AWS severity.

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REFERENCES

  1. Girard, M., Malauzat, D., and Nubukpo, P., World J. Biol. Psychiatry, 2019, vol. 20, no. 1, pp. 76–90. https://doi.org/10.1080/15622975.2017.1349338

    Article  PubMed  Google Scholar 

  2. Coccini, T., Ottonello, M., Spigno, P., Malovini, A., Fiabane, E., Roda, E., Signorini, C., and Pistarini, C., Alcohol, 2021, vol. 94, pp. 43–56. https://doi.org/10.1016/j.alcohol.2021.04.004

    Article  CAS  PubMed  Google Scholar 

  3. Harper, C. and Kril, J., J. Neurol. Neurosurg. Psychiatry, 1985, vol. 48, no. 3, pp. 211–217. https://doi.org/10.1136/jnnp.48.3.211

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Fein, G., di Sclafani, V., Cardenas, V.A., Gold-mann, H., Tolou-Shams, M., and Meyerhoff, D.J., Alcohol. Clin. Exp. Res., 2002, vol. 26, no. 4, pp. 558–564.

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Pfefferbaum, A., Rosenbloom, M., Rohlfing, T., and Sullivan, E.V., Biol. Psychiatry, 2009, vol. 65, no. 8, pp. 680–690. https://doi.org/10.1016/j.biopsych.2008.10.039

    Article  CAS  PubMed  Google Scholar 

  6. Altshuler, V.B., Serova, L.A., Kravchenko, S.L., Korolkov, A.I., Zaritskaya, V.A., and Khodikina, L.A., Zh. Vopr. Narkol., 2013, vol. 6, pp. 176–191.

    Google Scholar 

  7. Topiwala, A., Allan, C.L., Valkanova, V., Zsoldos, E., Filippini, N., Sexton, C., Mahmood, A., Fooks, P., Singh-Manoux, A., Mackay, C.E., Kivimäki, M., and Ebmeier, K.P., BMJ, 2017, vol. 357, p. j2353. https://doi.org/10.1136/bmj.j2353

    Article  PubMed  PubMed Central  Google Scholar 

  8. Ron, D. and Berger, A., Psychopharmacology (Berlin), 2018, vol. 235, no. 6, pp. 1727–1743. https://doi.org/10.1007/s00213-018-4882-z

    Article  CAS  Google Scholar 

  9. Liran, M., Rahamim, N., Ron, D., and Barak, S., Cold Spring Harb. Perspect. Med., 2020, vol. 10, no. 12, p. a039271. https://doi.org/10.1101/cshperspect.a039271

    Article  CAS  PubMed  Google Scholar 

  10. Kethawath, S.M., Jain, R., Dhawan, A., and Sarkar, S., Indian J. Psychiatry, 2020, vol. 62, no. 1, pp. 15–20. https://doi.org/10.4103/psychiatry.IndianJPsychiatry_134_19

    Article  PubMed  PubMed Central  Google Scholar 

  11. Mach, A. and Gromadzka, G., Alcohol Drug. Addict., 2020, vol. 33, no. 4, pp. 313–340. https://doi.org/10.5114/ain.2020.104815

    Article  Google Scholar 

  12. Varendi, K., Mätlik, K., and Andressoo, J.O., Cell. Mol. Life Sci., 2015, vol. 72, no. 9, pp. 1779–1794. https://doi.org/1007/s00018-015-1836-z

  13. Darcq, E., Warnault, V., Phamluong, K., Besserer, G.M., Liu, F., and Ron, D., Mol. Psychiatry, 2015, vol. 20, no. 10, pp. 1219–1231. https://doi.org/10.1038/mp.2014.120

    Article  CAS  PubMed  Google Scholar 

  14. Ehinger, Y., Phamluong, K., Darevesky, D., Welman, M., Moffat, J.J., Sakhai, S.A., White-ley, E.L., Berger, A.L., Laguesse, S., Farokhnia, M., Leggio, L., Lordkipanidzé, M., and Ron, D., Addict. Biol., 2021, vol. 26, no. 2, p. e12890. https://doi.org/10.1111/adb.12890

    Article  CAS  PubMed  Google Scholar 

  15. Ignacio, C., Hicks, S.D., Burke, P., Lewis, L., Szombathyne-Meszaros, Z., and Middleton, F.A., BMC Neurosci., 2015, vol. 16, p. 55. https://doi.org/10.1186/s12868-015-0195-x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Torres, J.L., Novo-Veleiro, I., Manzanedo, L., Alvela-Suárez, L., Macías, R., Laso, F.J., and Marcos, M., World J. Gastroenterol., 2018, vol. 24, no. 36, pp. 4104–4118. https://doi.org/10.3748/wjg.v24.i36.4104

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Neufeld, M., Bunova, A., Ferreira-Borges, C., Bryun, E., Fadeeva, E., Gil, A., Gornyi, B., Khaltourina, D., Koshkina, E., Nadezhdin, A., Tetenova, E., Vujnovic, M., Vyshinsky, K., Yurasova, E., and Rehm, J., Subst. Abuse Treat. Prev. Policy, 2021, vol. 16, no. 1, p. 76. https://doi.org/10.1186/s13011-021-00404-8

    Article  PubMed  PubMed Central  Google Scholar 

  18. Sobell, L.C. and Sobell, M.B., Measuring Alcohol Consumption: Psychosocial and Biological Methods, Litten, R.Z. and Allen, J.P., Eds., Humana Press, Totowa, NJ, 1992, pp. 41–72.

    Google Scholar 

  19. Pittman, B., Gueorguieva, R., Krupitsky, E., Rudenko,A.A., Flannery, B.A., and Krystal, J.H., Clin. Exp. Res., 2007, vol. 31, no. 4, pp. 612–618. https://doi.org/10.1111/j.1530-0277.2007.00345.x

    Article  Google Scholar 

  20. Flannery, B.A., Volpicelli, J.R., and Pettinati, H.M., Alcohol. Clin. Exp. Res., 1999, vol. 23, no. 8, pp. 1289–1295.

    Article  CAS  PubMed  Google Scholar 

  21. Ivanets, N.N., Kinkulkina, M.A., Avdeeva, T.I., and Sysoeva, V.P., Zh. Nevrol. Psikhiatr. im. S. S. Korsakova, 2016, vol. 116, no. 6, pp. 31–41.

    Article  CAS  PubMed  Google Scholar 

  22. Makhortova, I.S. and Shiryaev, O.Yu., Zh. Nevrol. Psikhiatr. im. S.S. Korsakova, 2017, vol. 117, no. 11, pp. 64–68.

    Article  CAS  PubMed  Google Scholar 

  23. Freud, T., Vostrikov, A., Dwolatzky, T., Punchik, B., and Press, Y., Front. Med. (Lausanne), 2020, vol. 7, p. 447. https://doi.org/10.3389/fmed.2020.00447

    Article  Google Scholar 

  24. Donati, S., Ciuffi, S., and Brandi, M.L., Int. J. Mol. Sci., 2019, vol. 20, no. 18, p. 4353. https://doi.org/10.3390/ijms20184353

    Article  CAS  PubMed Central  Google Scholar 

  25. Wu, S.Y., Chen, C.Y., Huang, T.L., and Tsai, M.C., Medicine (Baltimore), 2020, vol. 99, no. 17, p. e19938. https://doi.org/10.1097/MD.0000000000019938

    Article  CAS  PubMed Central  Google Scholar 

  26. Guo, L., Yin, M., and Wang, Y., Oncol. Lett., 2018, vol. 16, no. 3, pp. 3842–3848. https://doi.org/10.3892/ol.2018.9118

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Heberlein, A., Muschler, M., Wilhelm, J., Frieling, H., Lenz, B., Gröschl, M., Kornhuber, J., Bleich, S., and Hillemacher, T., Prog. Neuropsychopharmacol. Biol. Psychiatry, 2010, vol. 34, no. 6, pp. 1060–1064. https://doi.org/10.1016/j.pnpbp.2010.05.025

    Article  CAS  PubMed  Google Scholar 

  28. Huang, M.C., Chen, C.H., Chen, C.H., Liu, S.C., Ho, C.J., Shen, W.W., and Leu, S.J., Alcohol Alcohol., 2008, vol. 43, no. 3, pp. 241–245. https://doi.org/10.1093/alcalc/agm172

    Article  CAS  PubMed  Google Scholar 

  29. Joe, K.H., Kim, Y.K., Kim, T.S., Roh, S.W., Choi, S.W., Kim, Y.B., Lee, H.J., and Kim, D.J., Alcohol. Clin. Exp. Res., 2007, vol. 31, no. 11, pp. 1833–1838. https://doi.org/10.1111/j.1530-0277.2007.00507.x

    Article  CAS  PubMed  Google Scholar 

  30. Portelli, J., Farokhnia, M., Deschaine, S.L., Battista,J.T., Lee, M.R., Li, X., Ron, D., and Leggio, L., Alcohol, 2020, vol. 89, pp. 75–83. https://doi.org/10.1016/j.alcohol.2020.07.009

    Article  PubMed  PubMed Central  Google Scholar 

  31. Levchuk, L.A., Meeder, E.M.G., Roschina, O.V., Loonen, A.J.M., Boiko, A.S., Michalitskaya, E.V., Epimakhova, E.V., Losenkov, I.S., Simutkin, G.G., Bokhan, N.A., Schellekens, A.F.A., and Ivanova, S.A., Front. Psychiatry, 2020, vol. 11, p. 296. https://doi.org/10.3389/fpsyt.2020.00296

    Article  PubMed  PubMed Central  Google Scholar 

  32. Miao, Z., Zhang, J., Li, Y., Li, X., Song, W., Sun, Z.S., and Wang, Y., Neuropharmacology, 2019, vol. 159, p. 107589. https://doi.org/10.1016/j.neuropharm.2019.03.032

    Article  CAS  PubMed  Google Scholar 

  33. Cattaneo, A., Suderman, M., Cattane, N., Mazzelli, M., Begni, V., Maj, C., D’Aprile, I., Pariante, C.M., Luoni, A., Berry, A., Wurst, K., Hommers, L., Domschke, K., Cirulli, F., Szyf, M., Menke, A., and Riva, M.A., Neurobiol. Stress, 2020, vol. 13, p. 100271. https://doi.org/10.1016/j.ynstr.2020.100271

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Han, C., Bae, H., Won, S.D., Roh, S., and Kim, D.J., Ann. Gen. Psychiatry, 2015, vol. 14, p. 30. https://doi.org/10.1186/s12991-015-0065-z

    Article  PubMed  PubMed Central  Google Scholar 

  35. Nubukpo, P., Ramoz, N., Girard, M., Malauzat, D., and Gorwood, P., Alcohol. Clin. Exp. Res., 2017, vol. 41, no. 7, pp. 1280–1287. https://doi.org/10.1111/acer.13414

    Article  CAS  PubMed  Google Scholar 

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Funding

The study was carried out within the state assignment on the topic Study of the Pathogenetic Mechanisms of the Formation of Addiction to Psychoactive Substances Using Genetic, Biochemical, Immunological, Neurophysiological, and Neurocognitive Approaches (reg. no. 121041300174-8).

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Authors and Affiliations

  1. National Scientific Center for Narcology—a Branch of the Serbsky Federal Medical Research Centre of Psychiatry and Narcology of the Ministry of Health of the Russian Federation, 119002, Moscow, Russia

    D. I. Peregud, A. I. Korolkov, V. Y. Baronets, A. S. Lobacheva, M. L. Arkus, S. A. Igumnov & N. N. Terebilina

  2. Sechenov First Moscow State Medical University, 119991, Moscow, Russia

    S. V. Pirozhkov

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  1. D. I. Peregud
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  2. A. I. Korolkov
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  7. S. V. Pirozhkov
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  8. N. N. Terebilina
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Correspondence to D. I. Peregud.

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Conflict of interest. The authors declare no conflict of interest.

Ethical approval. The study protocol complied with the Declaration of Helsinki and was approved by the local ethics committee (protocol no. 36/9 of December 6, 2021). All patients gave written informed consent to participate in the study.

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Translated by A. Deryabina

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Peregud, D.I., Korolkov, A.I., Baronets, V.Y. et al. Contents of BDNF, miR-30a-5p AND miR-122 during Alcohol Withdrawal Syndrome. Biochem. Moscow Suppl. Ser. B 16, 353–363 (2022). https://doi.org/10.1134/S1990750822040060

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