Abstract
The effect of graphene oxide (GO) nanoparticles of 100–200 nm in size coated with linear (LP-GO) and branched (BP-GO) polyethylene glycol at concentrations of 5 and 25 μg/mL on the metabolism of Jurkat tumor cells was studied. It was found that LP-GO nanoparticles at a concentration of 25 μg/mL can enhance basal glycolysis of Jurkat T-lymphocyte tumor cell line cells, while LP-GO and BP-GO at the same concentration can reduce the indicators of compensatory glycolysis. Despite this, GO nanoparticles coated with linear and branched PEG at a concentration of 5 μg/mL do not have pronounced effects on oxidative phosphorylation and glycolysis of Jurkat cells and could therefore be safe for activated T cells.
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The study was supported by the Russian Science Foundation (project no. 19-15-00244).
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The authors declare that they have no conflicts of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.
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Translated by M. Batrukova
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Timganova, V.P., Vlasova, V.V., Bochkova, M.S. et al. Effect of PEGylated Graphene Oxide Nanoparticles on the Metabolism of Jurkat Cells. Dokl Biochem Biophys 512, 288–291 (2023). https://doi.org/10.1134/S1607672923700473
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DOI: https://doi.org/10.1134/S1607672923700473