Abstract
LOX (Lysyl oxidase) family participates in the catalysis of collagen and elastin to maintain ECM homeostasis. Glioma is the most common primary brain tumor and LOX family has not been systemic studied in glioma. In this study, we found LOX family members are upregulated expressed in gliomas samples. A protein-protein interaction network (PPIN) was construct to visualize and understand the differential expression pattern, as well as functional annotation, for LOX family and their interacting proteins, which involved in collagen fibril organization and MAPK signaling pathway. Through subcellular localization distribution, the LOX family members distribute both intracellular and extracellular. All five LOX members are consistently significantly correlate with dendritic cell both in immune infiltrate of GBM and LGG. Survival analysis showed that high expression of LOX family is associated with a poor prognosis of gliomas patients. These analyses provide important clues to identify the potential biological roles for LOX family in gliomas, which might serve as diagnosis markers.
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Funding
This work was supported by Grants from the National Natural Science Foundation of China (no. 81672473), the Science and Technology Program of Guangdong (2017A030313181).
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Conceptualization, Zepeng Du, Enmin Li and Bingli Wu; Methodology and Investigation, Weijie Xie, Zhongte Peng, Xiao Zhou, Qiaoxi Xia, Mantong Chen, Xiaoqi Zheng and Hong Sun; Project administration, Haiying Zou and Liyan Xu; Writing-original draft, Weijie Xie. All authors have read and agreed to the published version of the manuscript.
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The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
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The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.
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Xie, W., Peng, Z., Zhou, X. et al. The Expression Pattern and Clinical Significance of Lysyl Oxidase Family in Gliomas. Dokl Biochem Biophys 510, 132–143 (2023). https://doi.org/10.1134/S1607672922600269
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DOI: https://doi.org/10.1134/S1607672922600269