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Cryosynthesis of nanosized drug substances

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Abstract

The specific features of cryochemical technology for producton of new nanosized modifications of drug substances are observed. The method is based on transformation of the initial substance in gas phase and followed by the organization of molecular flow to the cooled surfaces. The results of study of physicochemical properties of nanosized drug substances obtained for different applications are presented: cardiological carvedilol, cytostatic imatinibe mesilate, steroid hormone Δ5 androstendiol-3β,17β, psychoactive phenasepam. On example of the last compound the results of biological tests are presented.

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References

  1. Nanoscale Materials in Chemistry, 2 ed., Klabunde K.J. and Richards, R.M., Eds., Hoboken (New Jersey): Wiley, 2009, 660-dc22 2008053437 US.

    Google Scholar 

  2. Sergeev, G.B. and Klabunde, K.J., in Nanochemistry, 2 ed., Amsterdam: Elsevier, 2013.

    Google Scholar 

  3. Bochenkov, V.E. and Sergeev, G.B., Russ. Chem. Rev., 2007, vol. 76, no. 11, p. 1084.

    Article  Google Scholar 

  4. Ruoslahti, E., Bhatia, S.N., and Sailor, M.J., J. Cell Biol., 2010, vol. 188, no. 6, pp. 759–768.

    Article  CAS  Google Scholar 

  5. Utekhina, A.Yu. and Sergeev, G.B., Russ. Chem. Rev., 2011, vol. 80, no. 3, pp. 219.

    Article  CAS  Google Scholar 

  6. Polymorphism: in the Pharmaceutical Industry, Hilfiker, R., Ed., Weinheim: Wiley, 2006.

    Google Scholar 

  7. RF Patent 2295511.

  8. Morozov, Yu.N., Mikhalev, S.P., Shabatin, V.P., Kolotilov, P.N., and Sergeev, G.B., Vestn. Mosk. Gos. Univ., Ser. 2: Khim., vol. 51, no. 4, pp. 288–295.

  9. Knudsen, M., Ann. Phys., 1909, no. 29, p. 179

    Google Scholar 

  10. Portnov, V.M. and Chuprunov, E.V., Vozniknovenie i rost krystallov (Crystal Formation and Growth), Moscow, Phyzmatlit, 2006

    Google Scholar 

  11. RF Patent 2366653.

  12. Sergeev, B.M., Mikhalev, S.P., Morozov, Yu.N., Shabatin, V.P., Kolotilov, P.N., and Sergeev, G.B., Vestn. Mosk. Gos. Univ., Ser. 2: Khim., vol. 51, no. 6, pp. 440–444.

  13. RF Patent 2365587.

  14. WO Patent 2004/106326 A1.

  15. Whitnall, M.H., Villa, V., Seed, T.M., and Benjack, J., Immunopharmacol. Immunotoxicol., 2005, vol. 27, pp. 15–32.

    Article  CAS  Google Scholar 

  16. Utekhina, A.Yu., Moskova, A.A., Morozov, Yu.N., Kolotilov, P.N., Sergeev, B.M., and Sergeev, G.B., Butlerov. Soobshch., 2011, vol. 25, no. 6, pp. 71–76.

    Google Scholar 

  17. RF Patent 2430094.

  18. RF Patent 2440120.

  19. Sergeev, G.B., Sergeev B.M., Morozov, Yu.N., and Chernyshev, V.V., Acta Crystallogr.: Sect. E., 2010, vol. 66, p. o2623.

    CAS  Google Scholar 

  20. Karapetyan, A.A., Andrianov, V.G., Struchkov, Yu.T., Bogatskii, A.V., Andronati, S.A., and Korotenko, T.I., Bioorg. Khim., 1979, vol. 5, no. 11, pp. 1684–1690.

    CAS  Google Scholar 

  21. Lipinski, C., Am. Pharm. Rev., 2002, vol. 5, pp. 82–85.

    Google Scholar 

  22. Keck, C.M. and Müller, R., Eur. J. Pharm. Biopharm., 2013, vol. 84, no. 3, pp. 445–448. doi: http://dx.doi.org/10.1016/j.ejpb.2013.01.001.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Lomonosov Moscow State University, Moscow, 119991, Russia

    Yu. N. Morozov, A. Yu. Utekhina, V. P. Shabatin, V. V. Chernyshev & G. B. Sergeev

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  1. Yu. N. Morozov
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  2. A. Yu. Utekhina
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  3. V. P. Shabatin
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  4. V. V. Chernyshev
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  5. G. B. Sergeev
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Corresponding author

Correspondence to Yu. N. Morozov.

Additional information

Original Russian Text © Yu.N. Morozov, A.Yu. Utekhina, V.P. Shabatin, V.V. Chernyshev, G.B. Sergeev, 2012, published in Rossiiskii Khimicheskii Zhurnal, 2012, Vol. 56, Nos. 5–6, pp. 43–51.

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Morozov, Y.N., Utekhina, A.Y., Shabatin, V.P. et al. Cryosynthesis of nanosized drug substances. Russ J Gen Chem 84, 1010–1017 (2014). https://doi.org/10.1134/S1070363214050387

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  • DOI: https://doi.org/10.1134/S1070363214050387

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