Abstract
Complex formation in solutions containing Ni2+ cations, glycine anions (Gly−), and β-lactam antibiotics, namely, ampicillin (Amp), amoxicillin (Axn), and cephalexin (Cpx), is studied by pH-metric titration at 20°C and an ionic strength of 0.1 (KNO3). Mixed-ligand complexes [NiGlyAmp], [NiGlyAxn], and [NiGlyCpx], which are in equilibrium with the [NiGly]+ complexes, are formed in the systems studied in a weakly alkaline medium. The formation constants of the complexes are determined. The distribution diagrams of the complex Ni(II) forms at different pH values of the solutions are constructed.
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References
Kozlovski, Kh., Ross. Khim. Zh., 2004, vol. 48, no. 1, p. 25.
Soldatenkov, A.T., Kolyadina, N.M., and Shendrik, I.V., Osnovy organicheskoi khimii lekarstvennykh veshchestv (Foundations of the Organic Chemistry of Pharmaceutical Agents), Moscow: Mir, 2003.
Alekseev, V.G., Demskaya, E.V., and Dodonova, M.S., Zh. Obshch. Khim., 2005, vol. 75, no. 6, p. 1049 [Russ. J. Gen. Chem. (Engl. Transl.), vol. 75, no. 6, 993].
Alekseev, V.G., Demskaya, E.V., Milashs, E.A., and Igolkin, V.V., Zh. Obshch. Khim., 2005, vol. 75, no. 7, p. 1211 [Russ. J. Gen. Chem. (Engl. Transl.), vol. 75, no. 7, 1147].
Alekseev, V.G., Dalandutskaya, V.S., Markelova, S.V., and Avilkina, A.A., Zh. Obshch. Khim., 2005, vol. 75, no. 8, p. 1349 [Russ. J. Gen. Chem. (Engl. Transl.), vol. 75, no. 8, 1280].
Fazakerley, G.V. and Jackson, G.E., J. Pharm. Sci., 1977, vol. 66, no. 4, p. 533.
Kapetanovic, V., Suznjevic, D., and Veselinovic, D., Electroanalysis, 1990, vol. 2, no. 6, p. 481.
Shoukry, M., Talanta, 1992, vol. 39, no. 12, p. 1625.
Lyle, S.J. and Yassin, Sh.S., Anal. Chim. Acta, 1993, vol. 274, no. 2, p. 225.
Mukherjee, G.N. and Ghosh, T.K., J. Indian Chem. Soc., 1994, vol. 71, no. 4, p. 169.
Mukherjee, G.N. and Ghosh, T.K., J. Inorg. Biochem., 1995, vol. 59, no. 4, p. 827.
Mukherjee, G.N. and Ghosh, T.K., Proc. Indian Acad. Sci. (Chem. Sci.), 1996, vol. 108, no. 4, p. 371.
Zayed, M.A. and Abdallah, S.M., Spectrochim. Acta, 2005, vol. 61, no. 9, p. 2231.
Alekseev, V.G., Shcherbakova, E.E., Yakubovich, Yu.Ya., et al., Zh. Obshch. Khim., 2006, vol. 76, no. 2, p. 338.
Alekseev, V.G., Nikiforova, A.A., and Markelova, S.V., Zh. Obshch. Khim., 2006, vol. 76, no. 9, p. 1531 [Russ. J. Gen. Chem. (Engl. Transl.), vol. 76, no. 9, p. 1468].
Alekseev, V.G., Lyamtseva, O.I., and Samuilova, I.S., Zh. Neorg. Khim., 2007, vol. 52, no. 3 [Russ. J. Inorg. Chem. (Engl. Transl.), vol. 52, no. 3].
Braibanti, A., Ostacoli, G., and Paoletti, P., et al., Pure Appl. Chem., 1987, vol. 59, no. 12, p. 1721.
Kiss, T., Sovago, I., and Gergely, A., Pure Appl. Chem., 1991, vol. 63, no. 4, p. 597.
Marshall, W.L. and Frank, E.U., J. Phys. Chem. Ref. Data, 1981, vol. 10, no. 2, p. 295.
Hamer, W.J. and Wu, Y.C., J. Phys. Chem. Ref. Data, 1972, vol. 1, no. 4, p. 1047.
Nazarenko, V.A., Antonovich, V.P., and Nevskaya, E.M., Gidroliz ionov metallov v razbavlennykh rastvorakh (Hydrolysis of Metal Ions in Dilute Solutions), Moscow: Atomizdat, 1979.
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Original Russian Text © V.G. Alekseev, I.S. Samuilova, 2007, published in Koordinatsionnaya Khimiya, 2007, Vol. 33, No. 12, pp. 930–933.
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Alekseev, V.G., Samuilova, I.S. Complex formation in nickel(II)-glycine-β-lactam antibiotic systems. Russ J Coord Chem 33, 914–917 (2007). https://doi.org/10.1134/S107032840712007X
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DOI: https://doi.org/10.1134/S107032840712007X