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Study of skin anti-ageing and anti-inflammatory effects of dihydroquercetin, natural triterpenoinds, and their synthetic derivatives

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Abstract

Accessible triterpenoids of ursane and lupane series, the flavonoid dihydroquercetin and their synthetic derivatives with polar substituents were tested in vitro for inhibition of collagenase 1 (MMP-1) in UVB irradiation assay. Ursolic acid and uvaol disuccinate were the most active inhibitors in the ursane series. In the lupane series, the best inhibition was manifested by carboxymethyl ester of betulonic acid and betulin succinates. Down- regulation of MMP-1 by dihydroquercetin and its synthetic derivatives surpassed the activity of a standard (retinoic acid).

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Abbreviations

MMP-1:

matrix metalloproteinase-1; collagenase-1

IL-8:

Interleukin-8

DMEM:

Dulbecco’s modified Eagle’s medium

FBS:

fetal bovine serum

PBS:

phosphate buffered saline

HaCaT cells:

Immortalized human Keratinocytes

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Authors and Affiliations

  1. Amore-Pacific Co. R&D Center, 314-1, Bora-dong, Giheung-gu, Yongin-si, Gyeonggi-Do, 446-729, Republic of Korea

    Chan Woo Lee & Nok Hyun Park

  2. Dept. of Applied Chemistry, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan, Kyeonggi-do, 426-791, Republic of Korea

    Jin Woong Kim

  3. Natural Products Research Center, Korea Institute of Science and Technology (KIST) Gangneung Institute, Gangneung, 210-340, Gangwon-do, Republic of Korea

    Byung Hun Um

  4. Novosibirsk Institute of Organic Chemistry, Lavrentyev Ave. 9, Novosibirsk, 630090, Russian Federation

    A. V. Shpatov, E. E. Shults, I. V. Sorokina & S. A. Popov

Authors
  1. Chan Woo Lee
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  2. Nok Hyun Park
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  3. Jin Woong Kim
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  4. Byung Hun Um
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  5. A. V. Shpatov
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  6. E. E. Shults
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  7. I. V. Sorokina
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  8. S. A. Popov
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Correspondence to Jin Woong Kim or S. A. Popov.

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Lee, C.W., Park, N.H., Kim, J.W. et al. Study of skin anti-ageing and anti-inflammatory effects of dihydroquercetin, natural triterpenoinds, and their synthetic derivatives. Russ J Bioorg Chem 38, 328–334 (2012). https://doi.org/10.1134/S1068162012030028

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  • DOI: https://doi.org/10.1134/S1068162012030028

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