Abstract
Arrays of potentiometric sensors with plasticized polymer membranes based on tetraalkylammonium organic ion exchanges with anions of penicillin class antibiotics (benzylpenicillin, ampicillin, oxacillin, and amoxicillin) have been proposed for the individual determination of antibiotics in model mixtures and pharmaceutical preparations. The following cross-sensitivity parameters of sensors have been estimated: the average slope of the electrode function (54 < S av < 61), the nonselectivity factor (2.8 < F < 74.6), and the reproducibility factor (31.9 < K < 61.2). Artificial neural networks have been applied to the treatment of analytical signals from the multisensor system in the concentration range 2.5 × 10−4–1 × 10−1 M. The average error of the individual determination of penicillin class antibiotics is 5–7%.
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References
Yakovlev, V.P. and Yakovlev, S.V., Ratsional’naya antimikrobnaya farmakoterapiya (Rational Antimicrobial Pharmacotherapy), Moscow: Litterra, 2007.
Gostishchev, V.K., Evseev, M.A., and Izotova, G.N., Russk. med. zhurn., 2006, vol. 14, no. 4, p. 3.
Sokolova, L.I. and Chernyaev, A.P., Zhurn. anal. khim., 2001, vol. 56, no. 11, p. 1177 [J. Anal. Chem. (Engl. Transl.), vol. 56, no. 11, p. 1032].
Benito-Peo, E., Partal-Rodera, A.I., Leonzoz, M.E., et al., Anal. Chim. Acta, 2006, vol. 556, no. 2, p. 415.
Akhmad, A.S., Rakhman, N., and Islam, F., Zhurn. anal. khim., 2004, vol. 59, no. 2, p. 138 [J. Anal. Chem. (Engl. Transl.), vol. 59, no. 2, p. 119].
Krasnikova, A.V. and Iozep, A.A., Khim-farm. zhurn., 2003, vol. 37, no. 9.
El Walily, M., Gazy, A., and Belal, S., Spectroscop. Lett., 2000, vol. 33, no. 6, p. 931.
Xiao, Y., Wang, H.Y., and Han, J., Spectrochim. Acta, 2005, vol. 61, no. 4, p. 567.
Santos, E.M.G., Arau’jo, A.N., Couto, C.M.C.M., et al., J. Pharm. Biomed. Anal., 2004, vol. 36, no. 4, p. 701.
Kulapina, E.G., Baraguzina, V.V., and Kulapina, O.I., Zhurn. anal. khim., 2004, vol. 59, no. 9, p. 971 [J. Anal. Chem. (Engl. Transl.), vol. 59, no. 9, p. 875].
Shvedene, N.V. and Borovskaya, S.V., Zhurn. anal. khim., 2003, vol. 58, no. 11, p. 1208 [J. Anal. Chem. (Engl. Transl.), vol. 58, no. 11, p. 1085].
Kulapina, E.G., Barinova, O.V., Kulapina, O.I., Utts, I.A., and Snesarev, S.V., Antibiot. khimioter., 2009, nos. 9–10, p. 53.
Turner, C., Rudnitskaya, A., and Legin, A., J. Biotechnol., 2003, vol. 103, p. 87.
Vlasov, Yu.G., Legin, A.V., and Rudnitskaya, A.M., Ross. khim. zhurn., 2008, vol. 7, no. 2, p. 101.
Kulapina, E.G., Mikhaleva, N.M., and Shmakov, S.L., Zhurn. anal. khim., 2004, vol. 59, no. 5, p. 547 [J. Anal. Chem. (Engl. Transl.), vol. 59, no. 5, p. 487].
Mikhaleva, N.M. and Kulapina, E.G., Zhurn. anal. khim., 2005, vol. 60, no. 6, p. 646 [J. Anal. Chem. (Engl. Transl.), vol. 60, no. 6, p. 573].
Alekseev, V.G. and Volkova, I.A., Zhurn. obshch. khim., 2003, vol. 73, no. 10, p. 1709 [Russ. J. Gen. Chem. (Engl. Transl.), vol. 73, no. 10, p. 1616].
Legin, A., Vlasov, Yu., Rudnitskaya, A., and Bychkov, E., Sens. Actuators B, 1996, vol. 34, p. 456.
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Original Russian Text © E.G. Kulapina, S.V. Snesarev, N.M. Makarova, E.S. Pogorelova, 2011, published in Zhurnal Analiticheskoi Khimii, 2011, Vol. 66, No. 1, pp. 82–87.
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Kulapina, E.G., Snesarev, S.V., Makarova, N.M. et al. Potentiometric sensor arrays for the individual determination of penicillin class antibiotics using artificial neural networks. J Anal Chem 66, 78–83 (2011). https://doi.org/10.1134/S1061934811010084
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DOI: https://doi.org/10.1134/S1061934811010084