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Allelic Combinations of Immune Response Genes and Risk of Development of Myocardial Infarction

  • Human Genetics
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Abstract

Myocardial infarction (MI) is a multifactorial polygenic disease. It develops because of the complex interaction between many environmental and genetic factors. In this paper, we have studied associations of MI and allele combinations of 17 polymorphic markers of immune response genes in an ethnically homogeneous group of Tatars. The material for analysis was DNA samples of patients (286 men) with onset of MI at the age of 30 to 60 years and 301 essentially healthy men of the control group. Using the APSampler algorithm, we obtained allele combinations with the increased risk of MI in which allele variants CX3CR1*M (rs3732378), VCAM1*C (rs3917010), ICAM1*E (rs5498), LTA*A (rs909253), and TNFRSF1B*M (rs1061622) occurred the most often.

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Authors and Affiliations

  1. Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of Sciences, Ufa, 450054, Russia

    T. R. Nasibullin, Ya. R. Timasheva, I. A. Tuktarova, V. V. Erdman & O. E. Mustafina

  2. Bashkir Republican Clinical Hospital of War Veterans, Ufa, 450002, Russia

    R. I. Sadikova

  3. Bashkir State Pedagogical University, Ufa, 450000, Russia

    M. Iu. Shein

  4. Republic Center of Cardiology, Ufa, 450106, Russia

    I. E. Nikolaeva

  5. Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, 450000, Russia

    O. E. Mustafina

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  1. R. I. Sadikova
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  2. T. R. Nasibullin
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  3. Ya. R. Timasheva
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  4. I. A. Tuktarova
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  6. M. Iu. Shein
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  7. I. E. Nikolaeva
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  8. O. E. Mustafina
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Correspondence to T. R. Nasibullin.

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Original Russian Text © R.I. Sadikova, T.R. Nasibullin, Ya.R. Timasheva, I.A. Tuktarova, V.V. Erdman, M.Iu. Shein, I.E. Nikolaeva, O.E. Mustafina, 2018, published in Genetika, 2018, Vol. 54, No. 4.

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Sadikova, R.I., Nasibullin, T.R., Timasheva, Y.R. et al. Allelic Combinations of Immune Response Genes and Risk of Development of Myocardial Infarction. Russ J Genet 54, 472–481 (2018). https://doi.org/10.1134/S1022795418040130

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