Abstract
To justify neurophysiological correlates of depressive disorders, the spetral parameters of EEG, peak latencies of the “late” components of auditory cognitive evoked potentials, and latencies of sensorimotor reactions in middle age and elderly patients (aged 53–72 years) during therapy of prolonged psychogenic depressive reaction (F43.21 according to ICD-10) have been studied. Initial depression severity was associated to the EEG signs of decreased functional state of the anterior areas of the left hemisphere and increased activation of the right hemisphere (especially, its temporal areas). Pronounced improvement of clinical state under the affect of psychopharmacotherapy was accompanied by acceleration of the sensorimotor reactions, a decrease in peak latencies of the “late” components (P2, N2, and P3) of auditory cognitive evoked potentials and associated with the EEG signs of improvement of functional state of the posterior areas of the brain, an enforcement of inhibitory processes in the right hemisphere (especially, in its frontal, central, and temporal areas) and more pronounced activation of frontal areas of the left hemisphere. The data are in good agreement with the concept on the systemic character of impairments of brain functioning in depression, as well as on the preferential role of the left hemisphere in control of positive emotions and the right one, of negative emotions.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Kessler, R.C., Berglund, P., Demler, O., et al., National Comorbidity Survey Replication. The Epidemiology of Major Depressive Disorder: Results from the National Comorbidity Survey Replication (NCS-R), JAMA, 2003, vol. 289, p. 3095.
Ustun, B.T. and Sartorius, N., Mental Illness in General Practice: An International Study, New York, 1995.
American EEG Society. Guidelines for Clinical EEG/EP Studies, J. Clin. Neuro-Physiol., 1993. Suppl. 1, p. 48.
Iznak, A.F., Instrumental’nye metody diagnostiki. Psikhiatriya: natsional’noe rukovodstvo (Instrumental Diagnostic Methods. Psychiatry: National Guidebook) Dmitrieva, T.B, Krasnova, V.N., Neznanova, N.G., Semke, V.Ya., and Tiganov, A.S,, Eds., Moscow: GEO-TAR-Media, 2009.
Gnezditskii, V.V., Vyzvannye Potentsialy Mozga V Klinicheskoi Praktike (Evoked Brain Potentials), Taganrog: TRTU, 1997, vol. 252.
Vsemirnaya Organizatsiya Zdravookhraneniya. MKB-10/ISD-10. Mezhdunarodnaya klassifikatsiya boleznei (10-i peresmotr): Klassifikatsiya psikhicheskikh i povedencheskikh rasstroistv. Klinicheskie opisaniya i ukazaniya po diagnostike (World Health Organization. MKB-10/ICD-10. International Classification of Diseases (10th Revision): Classification of Psychic and Behavioral Disorders. Clinical Descriptions and Diagnostic Instructions), St. Petersburg: Overlaid, 1994, p. 300.
Hamilton, M.Y., Psychopathology of Depressions: Quantitative Aspects, in Psychopathology of Depression, Helsinki, 1980, p. 201.
Mitrofanov, A.A., Komp’yuternaya sistema analiza i topograficheskogo kartirovaniya elektricheskoi aktivnosti mozga s neirometricheskim bankom EEG-dannykh (opisanie i primenenie) (Computer System of Analysis and Topographic Mapping of Electric Activity of the Brain with Neurometric Bank of EEG Data: Description and Use), Moscow, 2005.
Folstein, M.F., Folstein, S.E., and McHugh, P.R., Mini-Mental State Examination (MMSE), J. Psychiatr. Res., 1975, no. 12, p. 189.
Zhirmunskaya, E.A., Klinicheskaya elektroentsefalografiya (Clinic Electroencephalography), Moscow: Meibi, 1991.
Iznak, A.F., Neuronal Plasticity as One of Aspects of Pathogenesis and Treatment for Affective Disorders, Psikhiatr. Psikhofarmakoter., 2005, vol. 7, no. 1, p. 24.
Flor-Henry, P., Cerebral Basis of Psychopathology, Boston, 1983.
Chuprikov, A.P., Linev, A.N., and Martsenkovskii, I.A., Lateral’naya terapiya (Lateral Treatment), Kiev: Naukova Dumka, 1994.
Strelets, V.B., Avin, A.I., and Zverev, S.N., Mapping of Brain Potential in Patients with Depression Syndrome, Zh. Vyssh. Nervn. Deyat., 1990, vol. 40, no. 5, p. 903.
Orekhov, Yu.V., Golikova (Garakh) Zh.V., Strelets V.B., Psychophysiological Parameters of Mental Realization of Emotional States in Norm and Patients in the First Depression Episode, Zh. Vyssh. Nervn. Deyat., 2004, vol. 54, no. 5, p. 592.
Strelets, V.B., Garakh, Zh.V., and Novototskii-Vlasov, V.Yu., Comparative Study of Gamma-Rhythm in Norm, Examination Stress, and Patients in the First Depression Episode, Zh. Vyssh. Nervn. Deyat., 2006, vol. 56, no. 2, p. 219.
Fingelkurts, A.A., Fingelkurts, A.A., Rytsala, H., et al., Composition of Brain Oscillations in Ongoing EEG During Major Depressive Disorder, Neurosci. Res., 2006, vol. 56, no. 2, p. 133.
Thibodeau, R., Jorgensen, R.S., and Kim, S., Depression, Anxiety, and Resting Frontal EEG Asymmetry: a Meta-Analytic Review, J. Abnorm. Psychol., 2006, vol. 115, no. 4, p. 715.
Author information
Authors and Affiliations
Additional information
Original Russian Text © A.F. Iznak, E.V. Iznak, V.V. Kornilov, V.A. Kontsevoi, 2011, published in Fiziologiya Cheloveka, 2011, Vol. 37, No. 6, pp. 46–53.
Rights and permissions
About this article
Cite this article
Iznak, A.F., Iznak, E.V., Kornilov, V.V. et al. Neuropsychophysiological correlates of reactive depression. Hum Physiol 37, 682–687 (2011). https://doi.org/10.1134/S0362119711060089
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0362119711060089