Abstract
An online Raman analysis technique was used for the first time to study the mechanism underlying the synthesis of 5-bromomethylpyridine-2,3-dicarboxylic acid methyl ester (CMPE) via a bromination reaction with 5-methylpyridine-2,3-dicarboxylic acid dimethyl ester (MPE) as the raw material, N-bromosuccinimide (NBS) as the brominating reagent, and azobisisobutyronitrile (AIBN) as an initiator. The apparent thermodynamics and the reaction kinetics of bromination reaction of MPE were explored, a reaction kinetics model was established, and the bromination reaction of MPE was a typical reaction initiated by free radicals. The activation energy of bromination of MPE was 37.02 kJ mol–1, and the apparent reaction heat was 2.23 kJ mol–1 (calculated in the moles of NBS). The adiabatic temperature rise was 6.30°C under thermal runaway. The kinetic equation of the synthesis reaction: r = 3.26 × 106exp(–37.02/RT)\(C_{{{\text{NBS}}}}^{{1.52}}\).
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Ma, X., Liu, X., Ming, X. et al. Mechanism and Kinetics of Bromination of 5-Methylpyridine-2,3-dicarboxylic Acid Dimethyl Ester. Russ. J. Phys. Chem. 97, 73–79 (2023). https://doi.org/10.1134/S0036024423010338
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DOI: https://doi.org/10.1134/S0036024423010338