Abstract—
Results of an in vitro study demonstrate that, when brought in contact with tris-buffer, granules based on gelatin and synthetic ceramic powders containing varied percentages of Са10(РО4)6(ОН)2 and β-СаSiO3 rapidly degrade and swell, increasing in size by up to a factor of 1.2. After that, they gradually degrade, releasing calcium ions and phosphate and silicate anions to the solution. The systems with materials containing 20 to 60 wt % calcium silicate have been found to differ little in the concentrations of these ions. The weight loss of the composites, due to dissolution of the mineral components and gelatin, has been shown to exceed that of the apatite and wollastonite granules.
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REFERENCES
Morsy, R., Abuelkhair, R., and Elnimr, T., A facile route to the synthesis of hydroxyapatite/wollastonite composite powders by a two-step coprecipitation method, Silicon, 2015, vol. 9, pp. 637–641. https://doi.org/10.1007/s12633-015-9339-y
Baştan, F.E., Karaarslan, O., and Üstel, F., Production and characterization of wollastonite particles reinforced hydroxyapatite composite granules for biomedical applications, DEU FMD, 2021, vol. 23 (67), pp. 1–9. https://doi.org/10.21205/deufmd.2021236701
Padmanabhann, S.K., Gervaso, F., Carrozzo, M., Scalera, F., Sannino, A., and Licciulli, A., Wollastonite/hydroxyapatite scaffolds with improved mechanical, bioactive and biodegradable properties for bone tissue engineering, Ceram. Int., 2013, vol. 39, pp. 619–627. https://doi.org/10.1016/j.ceramint.2012.06.073
Buriti, J. da S., Barreto, M.E.V., Santos, K.O., and Fook, M.V.L., Thermal, morphological, spectroscopic and biological study of chitosan, hydroxyapatite and wollastonite biocomposites, J. Therm. Anal. Calorim., 2018, vol. 134, pp. 1521–1530. https://doi.org/10.1007/s10973-018-7498-y
Yu, H., Ning, C., Lin, K., and Chen, L., Preparation and characterization of PLLA/CaSiO3/apatite composite films, Int. J. Appl. Ceram. Technol., 2012, vol. 9, pp. 133–142. https://doi.org/10.1111/j.1744-7402.2010.02606.x
Encinas-Romero, M.A., Aguayo-Salinas, S., Castillo, S.J., Castillon-Barraza, F.F., and Castano, V.M., Synthesis and characterization of hydroxyapatite–wollastonite composite powders by sol–gel processing, Int. J. Appl. Ceram. Technol., 2008, vol. 5, pp. 401–411. https://doi.org/10.1111/j.1744-7402.2008.02212.x
Lin, K., Zhang, M., Zhai, W., Qu, H., and Chang, J., Fabrication and characterization of hydroxyapatite/wollastonite composite bioceramics with controllable properties for hard tissue repair, J. Am. Ceram. Soc., 2011, vol. 94, pp. 99–105. https://doi.org/10.1111/j.1551-2916.2010.04046.x
Encinas-Romero, M.A., Aguayo-Salinas, S., Valenzuela-Garcia, J.L., Payan, S.R., and Castillon-Barraza, F.F., Mechanical and bioactive behavior of hydroxyapatite–wollastonite sintered composites, Int. J. Appl. Ceram. Technol., 2010, vol. 7, pp. 164–177. https://doi.org/10.1111/j.1744-7402.2009.02377.x
Ryu, H.S., Lee, J.K., Kim, H., and Hong, K.S., New type of bioactive materials: hydroxyapatite/α-wollastonite composites, J. Mater. Res., 2005, vol. 20, pp. 1154–1162. https://doi.org/10.1557/JMR.2005.0144
Chen, Z., Zhai, J., Wang, D., and Chen, C., Bioactivity of hydroxyapatite/wollastonite composite films deposited by pulsed laser, Ceram. Int., 2018, vol. 44, no. 9, pp. 10204–10209. https://doi.org/10.1016/j.ceramint.2018.03.013
Beheri, H.H., Mohamed, K.R., and El-Bassyouni, G.T., Mechanical and microstructure of reinforced hydroxyapatite/calcium silicate nano-composites materials, Mater. Des., 2013, vol. 44, pp. 461–468. https://doi.org/10.1016/j.matdes.2012.08.020
Kokubo, T. and Takadama, H., How useful is SBF in predicting in vivo bone bioactivity?, Biomaterials, 2006, vol. 27, pp. 2907–2915. https://doi.org/10.1016/j.biomaterials.2006.01.017
Shevchenko, A.E., Solonenko, A.P., Blesman, A.I., Polonyankin, D.A., and Chikanova, E.S., Synthesis and physicochemical investigation of hydroxyapatite and wollastonite composite granules, J. Phys.: Conf. Ser., 2021, vol. 1791, p. 012119. https://doi.org/10.1088/1742-6596/1791/1/012119
Komlev, V.S., Barinov, S.M., and Koplik, E.V., A method to fabricate porous spherical hydroxyapatite granules intended for time-controlled drug release, Biomaterials, 2002, vol. 23, pp. 3449–3454. https://doi.org/10.1016/S0142-9612(02)00049-2
Hasan, M.L., Padalhin, A.R., Kim, B., and Lee, B.-T., Preparation and evaluation of BCP–CSD–agarose composite microsphere for bone tissue engineering, J. Biomed. Mater. Res. B, 2019, vol. 9999B, pp. 1–10. https://doi.org/10.1002/jbm.b.34318
Regulatory Guidelines 52.24.433-2005: Silicon mass concentration in surface water; technique of photometric determination in the form of yellow silicomolybdic acid, 2005.
Dorozhkin, S.V., Dissolution mechanism of calcium apatites in acids: a review of literature, World J. Methodol., 2012, vol. 26, no. 2 (1), pp. 1–17. https://doi.org/10.5662/wjm.v2.i1.1
Niu, L., Jiao, K., Wang, T., Zhang, W., Camilleri, J., Bergeron, B.E., Feng, H., Mao, J., Chen, J., Pashley, D.H., and Tay, F.R., A review of the bioactivity of hydraulic calcium silicate cements, J. Dent., 2014, vol. 42, no. 5, pp. 517–533. https://doi.org/10.1016/j.jdent.2013.12.015
Ni, S., Lin, K., Chang, J., and Chou, L., β-CaSiO3/ β‑Ca3(PO4)2 composite materials for hard tissue repair: in vitro studies, J. Biomed. Mater. Res. A, 2008, vol. 85, no. 1, pp. 72–82. https://doi.org/10.1002/jbm.a.31390
Veresov, A.G., Putlyaev, V.I., and Tret’yakov, Yu.D., Chemistry of calcium phosphate-based inorganic biomaterials, Ross. Khim. Zh., 2004, vol. 48, no. 4, pp. 52–64.
Hossana, M.J., Gafurb, M.A., Kadirb, M.R., and Karima, M.M., Preparation and characterization of gelatin–hydroxyapatite composite for bone tissue engineering, IJET–IJENS, 2014, vol. 14, no. 1, pp. 24–32.
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Solonenko, A.P., Shevchenko, A.E. & Polonyankin, D.A. Resorption Dynamics of Hydroxyapatite-, Wollastonite-, and Gelatin-Based Granules in Tris-Buffer. Inorg Mater 59, 329–336 (2023). https://doi.org/10.1134/S0020168523030147
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DOI: https://doi.org/10.1134/S0020168523030147