Abstract
The aim of this study is to find out whether maternal methyl-enriched diet affects the content of monoamines and their metabolites in brain structures of adult WAG/Rij offspring. It has been shown for the first time that maternal methyl-enriched diet (choline, betaine, folic acid, vitamin B12, L-methionine, zink) during the perinatal period increases dopaminergic tone of the mesolimbic brain system in adult offspring of WAG/Rij rats, which is accompanied by the suppression of the symptoms of genetic absence epilepsy and comorbid depression. Results suggest that maternal methyl-enriched diet during the perinatal period may be served as a new therapeutic strategy to prevent the development of a hypofunction of the mesolimbic dopaminergic brain system and associated genetic absence epilepsy and comorbid depression in offspring.
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The reported study was funded by RFBR, project no. 20-015-00327а.
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Statement on the welfare of animals. Experiments were performed in accordance with the European Union Directive 210/63/EU on the protection of animals used for scientific purposes and the principles formulated in the regulations adopted at IHNA and NPh RAS.
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Sarkisova, K.Y., Fedosova, E.A., Shatskova, A.B. et al. Maternal Methyl-Enriched Diet Increases Dopaminergic Tone of the Mesolimbic Brain System in Adult Offspring of WAG/Rij Rats. Dokl Biol Sci 506, 145–149 (2022). https://doi.org/10.1134/S001249662205012X
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DOI: https://doi.org/10.1134/S001249662205012X