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Features and Functions of the A-Minor Motif, the Most Common Motif in RNA Structure

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Abstract

A-minor motifs are RNA tertiary structure motifs that generally involve a canonical base pair and an adenine base forming hydrogen bonds with the minor groove of the base pair. Such motifs are among the most common tertiary interactions in known RNA structures, comparable in number with the non-canonical base pairs. They are often found in functionally important regions of non-coding RNAs and, in particular, play a central role in protein synthesis. Here, we review local variations of the A-minor geometry and discuss difficulties associated with their annotation, as well as various structural contexts and common A-minor co-motifs, and diverse functions of A-minors in various processes in a living cell.

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Authors and Affiliations

  1. Institute of Mathematical Problems of Biology RAS – the Branch of Keldysh Institute of Applied Mathematics of the Russian Academy of Sciences, 142290, Pushchino, Moscow Region, Russia

    Eugene F. Baulin

  2. Moscow Institute of Physics and Technology, 141701, Dolgoprudny, Moscow Region, Russia

    Eugene F. Baulin

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  1. Eugene F. Baulin
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Correspondence to Eugene F. Baulin.

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The authors declare no conflict of interest. This article does not contain any studies involving human participants or animals performed by any of the authors.

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Baulin, E.F. Features and Functions of the A-Minor Motif, the Most Common Motif in RNA Structure. Biochemistry Moscow 86, 952–961 (2021). https://doi.org/10.1134/S000629792108006X

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