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NMDA receptors in immune competent cells

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Abstract

This review presents analysis of literature data indicating the presence of NMDA-type glutamate receptors in several types of immune competent cells such as thymocytes, lymphocytes, and neutrophils. The possible role of these receptors in the function of these cells is discussed. The interaction of the receptors with certain ligands circulating in the blood-stream and their role in modulation of immune function is described. It is suggested that homocysteine acts as modulator of these receptors, and its toxicity is largely explained by hyperactivation of the NMDA-type glutamate receptors.

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Abbreviations

HC:

homocysteine

HCA:

homocysteic acid

MPO:

myeloperoxidase

NMDA:

N-methyl-D-aspartate

ROS:

reactive oxygen species

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Authors and Affiliations

  1. International Biotechnological Center, Lomonosov Moscow State University, 119991, Moscow, Russia

    A. A. Boldyrev, E. A. Bryushkova & E. A. Vladychenskaya

  2. Laboratory of Clinical Neurochemistry, Research Center of Neurology, Russian Academy of Medical Sciences, Volokolamskoe Shosse 80, 123367, Moscow, Russia

    A. A. Boldyrev

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  1. A. A. Boldyrev
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  2. E. A. Bryushkova
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  3. E. A. Vladychenskaya
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Correspondence to A. A. Boldyrev.

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Published in Russian in Biokhimiya, 2012, Vol. 77, No. 2, pp. 160–168.

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Boldyrev, A.A., Bryushkova, E.A. & Vladychenskaya, E.A. NMDA receptors in immune competent cells. Biochemistry Moscow 77, 128–134 (2012). https://doi.org/10.1134/S0006297912020022

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