Skip to main content
Log in

Telomerase activity in the bats Hipposideros armiger and Rousettus leschenaultia

  • Published:
Biochemistry (Moscow) Aims and scope Submit manuscript

Abstract

Telomerase activity was examined in two species of bat, Hipposideros armiger and Rousettus leschenaultia, which have similar body mass and lifespan but differ in use of hibernation. We found that telomerase activity was present in all tissues sampled, but it was greater in metabolically active tissues such as liver, spleen, and kidney. Of special interest is the raised activity found in the heterothermic bat H. armiger, and the hibernating bats having raised values for spleen, heart, and kidney. These findings show that maintenance of high levels of telomerase is an essential part of the regulation of cellular activities during hibernation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. De Lange, T. (2005) Genes Dev., 19, 2100–2110.

    Article  PubMed  Google Scholar 

  2. Blackburn, E. H. (1991) Nature, 350, 569–573.

    Article  PubMed  CAS  Google Scholar 

  3. Blackburn, E. H. (2000) Nature, 408, 53–56.

    Article  PubMed  CAS  Google Scholar 

  4. Kakuo, S., Asaoka, K., and Ide, T. (1999) Biochem. Biophys. Res. Commun., 263, 308–314.

    Article  PubMed  CAS  Google Scholar 

  5. Gardner, J. P., Kimura, M., Chai, W., Durrani, J. F., Tchakmakjian, L., Cao, X., Lu, X., Li, G., Peppas, A. P., Skurnick, J., Wright, W. E., Shay, J. W., and Aviv, A. (2007) J. Gerontol. A. Biol. Sci. Med. Sci., 62, 367–374.

    PubMed  Google Scholar 

  6. Harley, C. B., Futcher, A. B., and Greider, C. W. (1990) Nature, 345, 458–460.

    Article  PubMed  CAS  Google Scholar 

  7. Thomas, M., Yang, L., and Hornsby, P. J. (2000) Nat. Biotechnol., 18, 39–42.

    Article  PubMed  CAS  Google Scholar 

  8. Cui, W., Aslam, S., Fletcher, J., Wylie, D., Clinton, M., and Clark, A. J. (2002) J. Biol. Chem., 277, 38531–38539.

    Article  PubMed  CAS  Google Scholar 

  9. Zou, Y., Yi, X., Wright, W. E., and Shay, J. W. (2002) Exp. Cell. Res., 281, 63–76.

    Article  PubMed  CAS  Google Scholar 

  10. Argyle, D., Ellsmore, V., Gault, E. A., Munro, A. F., and Nasir, L. (2003) Mech. Ageing Dev., 124, 759–764.

    Article  PubMed  CAS  Google Scholar 

  11. Hartmann, N., and Scherthan, H. (2005) Exp. Cell. Res., 306, 64–74.

    Article  PubMed  CAS  Google Scholar 

  12. Campisi, J. (2001) Trends Cell Biol., 11, S27–S31.

    PubMed  CAS  Google Scholar 

  13. Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L., Coviello, G. M., Wright, W. E., Weinrich, S. L., and Shay, J. W. (1994) Science, 266, 2011–2015.

    Article  PubMed  CAS  Google Scholar 

  14. Prowse, K. R., and Greider, C. W. (1995) Proc. Natl. Acad. Sci. USA, 92, 4818–4822.

    Article  PubMed  CAS  Google Scholar 

  15. Wright, W., and Shay, J. (2000) Nat. Med., 6, 849–851.

    Article  PubMed  CAS  Google Scholar 

  16. Forsyth, N. R., Wright, W. E., and Shay, J. W. (2002) Differentiation, 69, 188–197.

    Article  PubMed  CAS  Google Scholar 

  17. Nunney, L. (1999) Proc. Biol. Sci., 266, 493–498.

    Article  PubMed  CAS  Google Scholar 

  18. Seluanov, A., Chen, Z., Hine, C., Sasahara, T. H., Ribeiro, A. A., Catania, K. C., Presgraves, D. C., and Gorbunova, V. (2007) Aging Cell, 6, 45–52.

    Article  PubMed  CAS  Google Scholar 

  19. Gorbunova, V., and Bozzella, J. M. (2008) AGE, 30, 111–119.

    Article  PubMed  Google Scholar 

  20. Gorbunova, V., and Seluanov, A. (2009) Mech. Ageing Dev., 130, 3–9.

    Article  PubMed  CAS  Google Scholar 

  21. Brunet-Rossini, A. K., and Austad, S. N. (2004) Biogerontology, 5, 211–222.

    Article  Google Scholar 

  22. Bourliere, M. D. J. (1958) Gerontology, 13, 16–24.

    Google Scholar 

  23. Austad, S. N., and Fischer, K. E. J. (1991) Gerontology, 46, B47–B53.

    CAS  Google Scholar 

  24. Wilkinson, G. S., and South, J. M. (2002) Aging Cell, 1, 124–131.

    Article  PubMed  CAS  Google Scholar 

  25. Geiser, F. (2004) Ann. Rev. Physiol., 66, 239–274.

    Article  CAS  Google Scholar 

  26. Lyman, C. P. (1970) in Biology of Bats (Wimsatt, W. A., ed.) Academic Press, Inc., New York, pp. 301–330.

    Google Scholar 

  27. Anthony, E. L. P. (1988) Age Determination in Bats, in Ecological and Behavioral Methods for the Study of Bats (Kunz, T. H., ed.) Smithsonian Institution Press, Washington DC, pp. 47–58.

    Google Scholar 

  28. Turturro, A., Witt, W. W., Lewis, S., Hass, B. S., Lipman, R. D., and Hart, R. W. (1999) J. Gerontol. Ser. A, 54, B492–B501.

    Article  CAS  Google Scholar 

  29. Wolfram, K., Klaus, H., Karen, K., Reza, P., and Guido, K. (1998) FEBS Lett., 434, 409–412.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Guimei He.

Additional information

Published in Russian in Biokhimiya, 2011, Vol. 76, No. 9, pp. 1248–1253.

Originally published in Biochemistry (Moscow) On-Line Papers in Press, as Manuscript BM11-097, July 3, 2011.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wang, L., McAllan, B.M. & He, G. Telomerase activity in the bats Hipposideros armiger and Rousettus leschenaultia . Biochemistry Moscow 76, 1017–1021 (2011). https://doi.org/10.1134/S0006297911090057

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0006297911090057

Key words

Navigation