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DNA polymerase ι of mammals as a participant in translesion synthesis of DNA

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Abstract

This review describes the properties of some specialized DNA polymerases participating in translesion synthesis of DNA. Special attention is given to these properties in vivo. DNA polymerase iota (Polι) of mammals has very unusual features and is extremely error-prone. Based on available data, a hypothesis is proposed explaining how mammalian cells can explore the unusual features of DNA Polι to bypass DNA damages and to simultaneously prevent its mutagenic potential.

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Abbreviations

APE1:

apurinic/apyrimidinic endonuclease 1

cisPt-GG:

cisplatinum adduct

csTT:

cis-syn-thymine-thymine dimer

HIF1:

hypoxia-inducible factor 1

HRE:

hypoxia response element

PARP1:

poly(ADP-ribose) polymerase 1

PCNA:

proliferating cell nuclear antigen

PIP1(PIP2):

PCNA interaction protein box

PNK:

polynucleotide kinase

Polι, Polη, Polζ, Polκ, RevI, Polβ, Polλ, Polα, Polδ, and Polɛ:

DNA polymerases ι, η, ζ, κ, RevI, β, λ, α, δ, and ɛ, respectively

RFC:

replication factor C

RPA:

replication protein A

XP-V:

xeroderma pigmentosum variant V

XRCC1:

X-ray repair complementing defective repair in Chinese hamster cells 1

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  1. Institute of Molecular Genetics, Russian Academy of Sciences, pl. Kurchatova 2, 123182, Moscow, Russia

    L. V. Gening

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Original Russian Text © L. V. Gening, 2011, published in Biokhimiya, 2011, Vol. 76, No. 1, pp. 76–85.

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Gening, L.V. DNA polymerase ι of mammals as a participant in translesion synthesis of DNA. Biochemistry Moscow 76, 61–68 (2011). https://doi.org/10.1134/S0006297911010081

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