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D-Amino acid oxidase: Physiological role and applications

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Abstract

D-Amino acids play a key role in regulation of many processes in living cells. FAD-dependent D-amino acid oxidase (DAAO) is one of the most important enzymes responsible for maintenance proper level of D-amino acids. The most interesting and important data for regulation of the nervous system, hormone secretion, and other processes by D-amino acids as well as development of different diseases under changed DAAO activity are presented. The mechanism of regulation is complex and multi-parametric because the same enzyme simultaneously influences the level of different D-amino acids, which can result in opposing effects. Use of DAAO for diagnostic and therapeutic purposes is also considered.

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Abbreviations

7-ACA:

7-aminocephalosporanic acid

DAAO:

D-amino acid oxidase

NMDA:

N-methyl-D-aspartate

MTOB:

4-methylthio-2-oxobutyrate

pkDAAO, TvDAAO, and RgDAAO:

D-amino acid oxidases from porcine kidney, Trigonopsis variabilis, and Rhodotorula gracilis, respectively.

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Authors and Affiliations

  1. Chemistry Faculty, Lomonosov Moscow State University, 119992, Moscow, Russia

    S. V. Khoronenkova & V. I. Tishkov

  2. Innovations and High Technologies MSU Ltd., 109559, Moscow, Russia

    S. V. Khoronenkova

  3. Bach Institute of Biochemistry, Russian Academy of Sciences, Leninsky pr. 32, 119071, Moscow, Russia

    V. I. Tishkov

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Original Russian Text © S. V. Khoronenkova, V. I. Tishkov, 2008, published in Uspekhi Biologicheskoi Khimii, 2008, Vol. 48, pp. 359–376.

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Khoronenkova, S.V., Tishkov, V.I. D-Amino acid oxidase: Physiological role and applications. Biochemistry Moscow 73, 1511–1518 (2008). https://doi.org/10.1134/S0006297908130105

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