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Transport proteins of the ABC family and multidrug resistance of tumor cells

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Abstract

Some new data concerning the role of transport proteins of the ABC family in multidrug resistance (MDR) of human tumor cells, and problems connected with regulation of these proteins are considered. MDR is a complex phenomenon that may be caused simultaneously by several mechanisms functioning in one and the same cell. Among them there may be the alterations of activity of several transport proteins. Activation of these proteins may be associated with alterations of activities of different cell protective systems and of the signal transduction pathways involved in regulation of proliferation, differentiation, and apoptosis. Clinical significance of multifactor MDR is discussed.

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Abbreviations

AP:

acceleration phase

CML:

chronic myelogenous leukemia

CP:

chronic phase

MDR:

multidrug resistance

MDT:

transporters of multiple drugs

NBD:

nucleotide binding domains

Pgp:

P-glycoprotein

PI3K:

phosphoinosi-tol-3-kinase

PTEN:

phosphatase and tensin homolog

Rh123:

Rhodamine 123

RT-PCR:

reverse transcription polymerase chain reaction

TMD:

transmembrane binding domains

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  1. Institute of Carcinogenesis, Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Kashirskoe Shosse 24, 115478, Moscow, Russia

    A. A. Stavrovskaya & T. P. Stromskaya

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  1. A. A. Stavrovskaya
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Correspondence to A. A. Stavrovskaya.

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Original Russian Text © A. A. Stavrovskaya, T. P. Stromskaya, 2008, published in Biokhimiya, 2008, Vol. 73, No. 5, pp. 735–750.

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Stavrovskaya, A.A., Stromskaya, T.P. Transport proteins of the ABC family and multidrug resistance of tumor cells. Biochemistry Moscow 73, 592–604 (2008). https://doi.org/10.1134/S0006297908050118

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