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An endophytic Neurospora sp. from Nothapodytes foetida producing camptothecin

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Abstract

The medicinal plant, Nothapodytes foetida, contains a number of important alkaloids like camptothecin (an anticancer drug molecule), but its concentration is less to meet the existing demand of this important molecule, in an effort for accessible availability of camptothecin. An endophyte (designated ZP5SE) was isolated from the seed of Nothapodytes foetida and was examined as a potential source of anticancer drug lead compound, i.e., camptothecin, when grown in Sabouraud liquid culture media under shake flask conditions. The presence of an anticancer compound (camptothecin) in this fungus was confirmed by chromatographic and spectroscopic methods in comparison with authentic camptothecin. Isolated endophyte (Neurospora crassa) producing camptothecin may become an easily accessible source for the production of a precursor anticancer drug molecule in the future at a large scale.

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Authors and Affiliations

  1. Regional Research Laboratory, Sanat Nagar Srinagar, 190005, India

    S. Rehman, A. S. Shawl, A. Kour & P. Sultan

  2. Regional Research Laboratory, Jammu, India

    R. Andrabi, P. Sudan, V. Verma & G. N. Qazi

Authors
  1. S. Rehman
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  2. A. S. Shawl
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  3. A. Kour
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  4. R. Andrabi
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  5. P. Sudan
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  6. P. Sultan
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  7. V. Verma
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  8. G. N. Qazi
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Corresponding author

Correspondence to S. Rehman.

Additional information

Published in Russian in Prikladnaya Biokhimiya i Mikrobiologiya, 2008, Vol. 44, No. 2, pp. 225–231.

The text was submitted by the authors in English.

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Rehman, S., Shawl, A.S., Kour, A. et al. An endophytic Neurospora sp. from Nothapodytes foetida producing camptothecin. Appl Biochem Microbiol 44, 203–209 (2008). https://doi.org/10.1134/S0003683808020130

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  • DOI: https://doi.org/10.1134/S0003683808020130

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