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Superoxide scavenging activity of plastoquinone derivative 10-(6′-plastoquinonyl)decyltriphenylphosphonium (SkQ1)

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Abstract

The plastoquinone derivative 10-(6′-plastoquinonyl)decyltriphenylphosphonium (SkQ1) has the ability to scavenge superoxide anion radical. This ability is manifested both in vitro and in vivo in experiments with the bacterium Escherichia coli. The protective effect of SkQ1 in vivo significantly exceeds that of ascorbic acid.

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Abbreviations

HBO:

hyperbaric oxygenation

\(O_2^{ - \cdot } \) :

superoxide anion radical

SkQ1:

plastoquinone derivative 10-(6′-plastoquinonyl)decyltriphenylphosphonium

SOD:

superoxide dismutase

References

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Authors and Affiliations

  1. Rostov State Medical University, Pereulok Nakhichevanskii 29, 344022, Rostov-on-Don, Russia

    V. A. Chistyakov

  2. Research Institute of Biology, Southern Federal University, pr. Stachki 194/1, 344090, Rostov-on-Don, Russia

    V. A. Chistyakov, E. V. Prazdnova, L. V. Gutnikova, M. A. Sazykina & I. S. Sazykin

Authors
  1. V. A. Chistyakov
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  2. E. V. Prazdnova
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  3. L. V. Gutnikova
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  4. M. A. Sazykina
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  5. I. S. Sazykin
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Corresponding author

Correspondence to V. A. Chistyakov.

Additional information

Original Russian Text © V. A. Chistyakov, E. V. Prazdnova, L. V. Gutnikova, M. A. Sazykina, I. S. Sazykin, 2012, published in Biokhimiya, 2012, Vol. 77, No. 7, pp. 932–935.

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Chistyakov, V.A., Prazdnova, E.V., Gutnikova, L.V. et al. Superoxide scavenging activity of plastoquinone derivative 10-(6′-plastoquinonyl)decyltriphenylphosphonium (SkQ1). Biochemistry Moscow 77, 776–778 (2012). https://doi.org/10.1134/S0006297912070103

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  • DOI: https://doi.org/10.1134/S0006297912070103

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