Improvements in brain activation detection using time-resolved diffuse optical means

Bruno Montcel; Renee Chabrier; Patrick Poulet

doi:10.1117/12.632836

7 October 2005 Improvements in brain activation detection using time-resolved diffuse optical means

Bruno Montcel, Renee Chabrier, Patrick Poulet

Proceedings Volume 5859, Photon Migration and Diffuse-Light Imaging II; 58590G (2005) https://doi.org/10.1117/12.632836
Event: European Conferences on Biomedical Optics 2005, 2005, Munich, Germany

Abstract

An experimental method based on time-resolved absorbance difference is described. The absorbance difference is calculated over each temporal step of the optical signal with the time-resolved Beer-Lambert law. Finite element simulations show that each step corresponds to a different scanned zone and that cerebral contribution increases with the arrival time of photons. Experiments are conducted at 690 and 830 nm with a time-resolved system consisting of picosecond laser diodes, micro-channel plate photo-multiplier tube and photon counting modules. The hemodynamic response to a short finger tapping stimulus is measured over the motor cortex. Time-resolved absorbance difference maps show that variations in the optical signals are not localized in superficial regions of the head, which testify for their cerebral origin. Furthermore improvements in the detection of cerebral activation is achieved through the increase of variations in absorbance by a factor of almost 5 for time-resolved measurements as compared to non-time-resolved measurements.

Citation Download Citation

Bruno Montcel, Renee Chabrier, and Patrick Poulet "Improvements in brain activation detection using time-resolved diffuse optical means", Proc. SPIE 5859, Photon Migration and Diffuse-Light Imaging II, 58590G (7 October 2005); https://doi.org/10.1117/12.632836

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