A pilot study on less-stressful bowel preparation for virtual colonoscopy screening with follow-up biopsy by optical colonoscopy

Zhengrong Liang; Sarang Lakare; Mark Wax M.D.; Dongqing Chen; Lihong Li; Joseph Anderson M.D.; Arie Kaufman; Donald Harrington M.D.

doi:10.1117/12.597437

14 April 2005 A pilot study on less-stressful bowel preparation for virtual colonoscopy screening with follow-up biopsy by optical colonoscopy

Zhengrong Liang, Sarang Lakare, Mark Wax M.D., Dongqing Chen, Lihong Li, Joseph Anderson M.D., Arie Kaufman, Donald Harrington M.D.

Author Affiliations +

Proceedings Volume 5746, Medical Imaging 2005: Physiology, Function, and Structure from Medical Images; (2005) https://doi.org/10.1117/12.597437
Event: Medical Imaging, 2005, San Diego, California, United States

Abstract

Objective: To investigate a less stressful bowel preparation for polyp screening by virtual colonoscopy (VC) with follow-up biopsy on the positive findings by optical colonoscopy (OC). Materials and Methods: Fifty-eight volunteers of age older than 40 -- receiving low-residue diet and laxatives of magnesium citrate, bisacodyl tablets and suppository -- were divided into three groups. In Group I, 16 volunteers took three 40cc oral doses of MD-Gastroview with the three meals respectively, the day prior to VC procedure. In Group II, 18 volunteers ingested barium sulfate suspension (2% w/v, 250 cc/dose) at bedtime and in the next day morning of VC. In Group III, 24 volunteers received 60 cc of MD-Gastroview at bedtime and in the next day morning of VC. Following colon inflation with CO₂, computer tomography (CT) abdominal images were acquired by a standard single-slice detector-band VC protocol, i.e., 5 mm collimation, 1 mm reconstruction, 1.5-2.0:1.0 pitch, 120 kVp and 100-150 mA. The CT density of the tagged residual fluid was measured. An image segmentation algorithm was applied to remove electronically the residue fluid. Results: The average fluid density was 97 HU for Group I, 221 HU for Group II2, and 599 HU for Group III. These three groups’ density means are significantly different (p < 0.001 one-way ANOVA). After the electronic cleansing, the % of cleansed fluid regions was 5.5%, 16.5% and 93.1% (p<0.0001 Chi square) for these groups respectively. Conclusion: A less-stressful bowel preparation with low residue diet and MD-Gastroview oral contrast is feasible for VC screening with follow-up biopsy on the positive findings by OC.

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Zhengrong Liang, Sarang Lakare, Mark Wax M.D., Dongqing Chen, Lihong Li, Joseph Anderson M.D., Arie Kaufman, and Donald Harrington M.D. "A pilot study on less-stressful bowel preparation for virtual colonoscopy screening with follow-up biopsy by optical colonoscopy", Proc. SPIE 5746, Medical Imaging 2005: Physiology, Function, and Structure from Medical Images, (14 April 2005); https://doi.org/10.1117/12.597437

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