Design verification of a compact system for detecting tissue perfusion using bimodal diffuse optical technologies

Julia M. Pakela; Taylor L. Hedrick; Seung Yup Lee; Karthik Vishwanath; Sara Zanfardino; Yooree G. Chung; Michael C. Helton; Noah J. Kolodziejski; Christopher J. Stapels; Daniel R. McAdams; Daniel E. Fernandez; James F. Christian; Stephen E. Feinberg; Mary-Ann Mycek

doi:10.1117/12.2252811

17 February 2017 Design verification of a compact system for detecting tissue perfusion using bimodal diffuse optical technologies

Julia M. Pakela, Taylor L. Hedrick, Seung Yup Lee, Karthik Vishwanath, Sara Zanfardino, Yooree G. Chung, Michael C. Helton, Noah J. Kolodziejski, Christopher J. Stapels, Daniel R. McAdams, Daniel E. Fernandez, James F. Christian, Stephen E. Feinberg, Mary-Ann Mycek

Author Affiliations +

Proceedings Volume 10072, Optical Diagnostics and Sensing XVII: Toward Point-of-Care Diagnostics; 1007217 (2017) https://doi.org/10.1117/12.2252811
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

It is essential to monitor tissue perfusion during and after reconstructive surgery, as restricted blood flow can result in graft failures. Current clinical procedures are insufficient to monitor tissue perfusion, as they are intermittent and often subjective. To address this unmet clinical need, a compact, low-cost, multimodal diffuse correlation spectroscopy and diffuse reflectance spectroscopy system was developed. We verified system performance via tissue phantoms and experimental protocols for rigorous bench testing. Quantitative data analysis methods were employed and tested to enable the extraction of tissue perfusion parameters. This design verification study assures data integrity in future in vivo studies.

Citation Download Citation

Julia M. Pakela, Taylor L. Hedrick, Seung Yup Lee, Karthik Vishwanath, Sara Zanfardino, Yooree G. Chung, Michael C. Helton, Noah J. Kolodziejski, Christopher J. Stapels, Daniel R. McAdams, Daniel E. Fernandez, James F. Christian, Stephen E. Feinberg, and Mary-Ann Mycek "Design verification of a compact system for detecting tissue perfusion using bimodal diffuse optical technologies", Proc. SPIE 10072, Optical Diagnostics and Sensing XVII: Toward Point-of-Care Diagnostics, 1007217 (17 February 2017); https://doi.org/10.1117/12.2252811

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available