Vero毒素産生性大腸菌O111: H-による集団下痢症の細菌学的研究

田中 博; 大瀬戸 光明; 山下 育孝; 篠原 信之; 井上 博雄; 佐々木 嘉忠; 柿原 良俊; 塚本 定三; 湯通堂 隆; 奥 裕一; 竹田 美文

doi:10.11150/kansenshogakuzasshi1970.63.1187

Bacteriological Investigation on an Outbreak of Acute Enteritis associated with Verotoxin-producing Escherichia coli O111: H^-

Hiroshi TANAKA, Mitsuaki OHSETO, Yasutaka YAMASHITA, Nobuyuki SHINOHARA, Hiroo INOUE, Yoshitada SASAKI, Yoshitoshi KAKIHARA, Teizo TSUKAMOTO, Takashi YUTSUDO, Yuichi OKU, Yoshifumi TAKEDA

Author information

Hiroshi TANAKA
Ehime Prefectural Institute of Public Health
Mitsuaki OHSETO
Ehime Prefectural Institute of Public Health
Yasutaka YAMASHITA
Ehime Prefectural Institute of Public Health
Nobuyuki SHINOHARA
Ehime Prefectural Institute of Public Health
Hiroo INOUE
Ehime Prefectural Institute of Public Health
Yoshitada SASAKI
Ehime Prefectural Central Hospital
Yoshitoshi KAKIHARA
Ehime Prefectural Central Hospital
Teizo TSUKAMOTO
Osaka Prefectural Institute of Public Health
Takashi YUTSUDO
The Institute of Medical Seience, The University of Tokyo
Yuichi OKU
The Institute of Medical Seience, The University of Tokyo
Yoshifumi TAKEDA
The Institute of Medical Seience, The University of Tokyo

Keywords: Escherichia coli O111: H^-, Hemorrhagic colitis, Hemolytic uremic syndrome

JOURNAL FREE ACCESS

1989 Volume 63 Issue 10 Pages 1187-1194

DOI https://doi.org/10.11150/kansenshogakuzasshi1970.63.1187

Details

Abstract

An outbreak of acute enteritis in children aged one to thirty-three months occurred from June 10th to 23rd, 1986, at a private orphanage in Matsuyama City. Twenty-two out of 23 children suffered from diarrhea. Nine of the 22 children excreted bloody stool. Fever and vomiting were observed with a few patients. One of them, a 33-month-old girl, developed hemolytic uremic syndrome, and died twelve days after the admission.
Escherichia coli O111: H^- was isolated from fecal specimens of 7 out of 15 patients. The culture filtrate of the isolate caused fluid accumulation in ligated ileal loops in a rabbit, and was lethal to mice.
It wa found that all isolates produced two kinds of Vero toxins (VT1 and VT2, or shiga-like toxin I and II). The amount of VT2 produced in vitro was about 10 times more than that of VT1.

Corresponding author

Register with J-STAGE for free!