腎疾患, 血友病および健常献血者における抗HTLV-Iおよび抗HIV抗体の検討

河野 茂; 増山 泰治; 道津 安正; 宮崎 幸重; 古賀 宏延; 横山 一章; 田浦 幸一; 原田 孝司; 山口 恵三; 泉川 欣一; 広田 正毅; 斎藤 厚; 原 耕平; 木下 研一郎; 市丸 道人; 楊井 正紀; 辻 芳郎; 宮本 勉

doi:10.11150/kansenshogakuzasshi1970.61.567

Anti-HTLV-I Antibody and Anti-HIV Antibody in Hemophiliacs, Patients of Renal desease and Blood Donors

Shigeru KOHNO, Yasuharu MASUYAMA, Yasumasa DOHTSU, Takashige MIYAZAKI, Hironobu KOGA, Kazuaki YOKOYAMA, Kouichi TAURA, Takashi HARADA, Keizo YAMAGUCHI, Kinichi IZUMIKAWA, Masaki HIROTA, Atsushi SAITOH, Kohei HARA, Kenichiro KINOSHITA, Michito ICHIMARU, Masaki YANAI, Yoshiro TSUJI, Tsutomu MIYAMOTO

Author information

Shigeru KOHNO
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Yasuharu MASUYAMA
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Yasumasa DOHTSU
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Takashige MIYAZAKI
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Hironobu KOGA
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Kazuaki YOKOYAMA
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Kouichi TAURA
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Takashi HARADA
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Keizo YAMAGUCHI
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Kinichi IZUMIKAWA
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Masaki HIROTA
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Atsushi SAITOH
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Kohei HARA
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Kenichiro KINOSHITA
Department of Hematology, Nagasaki University School of Medicine
Michito ICHIMARU
Department of Hematology, Nagasaki University School of Medicine
Masaki YANAI
Department of Pediatrics, Nagasaki University School of Medicine
Yoshiro TSUJI
Department of Pediatrics, Nagasaki University School of Medicine
Tsutomu MIYAMOTO
Department of Microbiology, Nagasaki University School of Medicine

Keywords: Renal disease, Hemophilia, Blood donor, anti-HTLV-I antibody, Anti-HIV Antibody

JOURNAL FREE ACCESS

1987 Volume 61 Issue 5 Pages 567-573

DOI https://doi.org/10.11150/kansenshogakuzasshi1970.61.567

Details

Abstract

Anti-HTLV-I antibody and anti-HIV antibody were measured by ELISA in hemophiliacs, patients of hemodialysis or nephrosis syndrome and blood donors in order to investigate the infection of acquired immunodeficieny syndrome (AIDS) and adult T cell leukemia (ATL).
With regard to anti-HTLV-I antibody, 4 out of 13 cases (30.8%) in hemophila, 21 out of 75 cases (28.0%) in renal desease and 12 out of 500 cases (2.4%) in blood donor were positive, respectively. With regard to and-HIV antibody, both Abbott and Litton assays were evaluated in those patients. Antibody titers correlated well statistically in two assays, but false positive cases were found in 16 cases (2.7%) by Abbott and 5 cases (0.9%) by Litton out of 558 cases, respectively. Ten out of 13 hemophiliacs (76.9%) were positive of and-HIV antibody, but no case was positive in patients of renal desease and blood donors. Immunological investigation reveals that OKT4/8 ratio was remarkably lower (0.86) in anti-HIV antibody positive cases than in negative cases.

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