複雑性尿路感染症に対するT-1982 (Cefbuperazone) とCefmetazoleの比較検討

河田 幸道; 村中 幸二; 西浦 常雄; 大井 好忠; 岡元 健一郎; 斉藤 泰; 植田 省吾; 江藤 耕作; 百瀬 俊郎; 熊沢 浄一; 児玉 光人; 仁平 寛巳; 赤沢 信幸; 大森 弘之; 千種 一郎; 多田 茂; 大川 光央; 久往 治男; 岸 洋一; 新島 端夫; 小野寺 昭一; 町田 豊平; 上野 一恵; 田中 恒男

doi:10.11150/kansenshogakuzasshi1970.57.470

Comparative Studies of T-1982 (Cefbuperazone) and Cefmetazole In Complicated Urinary Tract Infections

Yukimichi KAWADA, Kouji MURANAKA, Tsuneo NISHIURA, Yoshitada OHI, Kenichiro OKAMOTO, Yutaka SAITO, Shogo UEDA, Kosaku ETO, Shunro MOMOSE, Joichi KUMAZAWA, Mitsuto KODAMA, Hiromi NIHIRA, Nobuyuki AKAZAWA, Hiroyuki OHMORI, Ichiro CHIGUSA, Shigeru TADA, Mitsuo OHKAWA, Haruo HISAZUMI, Hiroichi KISHI, Tadao NIIJIMA, Shoichi ONODERA, Toyohei MACHIDA, Kazuo UENO, Tsuneo TANAKA

Author information

Yukimichi KAWADA
Department of Urology, Gifu University School of Medicine
Kouji MURANAKA
Department of Urology, Gifu University School of Medicine
Tsuneo NISHIURA
Department of Urology, Gifu University School of Medicine
Yoshitada OHI
Department of Urology, Faculty of Medicine, Kagoshima University
Kenichiro OKAMOTO
Department of Urology, Faculty of Medicine, Kagoshima University
Yutaka SAITO
Department of Urology, Nagasaki University, School of Medicine
Shogo UEDA
Department of Urology, Kurume University, School of Medicine
Kosaku ETO
Department of Urology, Kurume University, School of Medicine
Shunro MOMOSE
Department of Urology, Faculty of Medicine, Kyushu University
Joichi KUMAZAWA
Department of Surgery, Division of Urology, Saga Medical School
Mitsuto KODAMA
Department of Urology, Faculty of Medicine, Hiroshima University
Hiromi NIHIRA
Department of Urology, Faculty of Medicine, Hiroshima University
Nobuyuki AKAZAWA
Department of Urology, Okayama University, Medical School
Hiroyuki OHMORI
Department of Urology, Okayama University, Medical School
Ichiro CHIGUSA
Department of Urology, Mie University, School of Medicine
Shigeru TADA
Department of Urology, Mie University, School of Medicine
Mitsuo OHKAWA
Department of Urology, School of Medicine Kanazawa University
Haruo HISAZUMI
Department of Urology, School of Medicine Kanazawa University
Hiroichi KISHI
Department of Urology, Faculty of Medicine, University of Tokyo
Tadao NIIJIMA
Department of Urology, Faculty of Medicine, University of Tokyo
Shoichi ONODERA
Department of Urology, The Jikei University, School of Medicine
Toyohei MACHIDA
Department of Urology, The Jikei University, School of Medicine
Kazuo UENO
Institute of Anaerobic Bacteriology, Gifu University School of Medicine
Tsuneo TANAKA
Department of Health Administration, School of Health Sciences, Faculty of Medicine, University of Tokyo

Keywords: Urinary tract infection, Double blind multi-clinical Study, T-1982 (Cefbuperazone), Cefmetazole

JOURNAL FREE ACCESS

1983 Volume 57 Issue 6 Pages 470-486

DOI https://doi.org/10.11150/kansenshogakuzasshi1970.57.470

[Correction] kansenshogakuzasshi Vol.57 No.8 (1983) pp.767-767

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Abstract

A double-blind comparison of T-1982 (cefbuperazone), a new cephamycin antibiotics and cefmetazole was carried out in the treatment of complicated urinary tract infections.Patients received either 0.5g of T-1982 or 1g of cefmetazole twice a day for 5 days by intravenous injection.
All patients had pyuria of 5 or more WBCs per high power field, bacteriuria of 10⁴ or more bacteria per ml of urine and underlying urinary disease. The overall clinical efficacy of the treatment was evaluated by the criteria proposed by the UTI Committee in Japan as excellent, moderate or poor.
Of the 241 patients admitted to the study, 119 received T-1982 and 122 received cefmetazole. No significant difference in background characteristics was observed between the two treatment groups.Excellent and moderate responses were obtained in 73.9% of the patients receiving T-1982 and 57.4% of the patients receiving cefmetazole. This difference was statistically significant (p<0.05). Clinical efficacies of T-1982 for the patients infected with Serratia were significantly higher than that of cefmetazole (p<0.01) and when patients infected with Serratia were excluded from both groups, no significant difference of clinical efficacies was observed.
Although significant difference was not observed in the overall bacteriological responses, eradication rate of Serratia was significantly higher in T-1982 group (p<0.01). Eradication rate of P.aeruginosa was markedly low in both groups.
There was no significant difference between the two treatment groups regarding the incidence of side effects and T-1982 appeared to be as well torelated as cefmetazole.
From the results obtained in this study, we concluded that T-1982 was useful in the treatment of complicated urinary tract infections except for those due to P. aeruginosa, especially in the treatment of those due to Serratia.

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