1975 Volume 49 Issue 11 Pages 584-592
Talampicillin (TAPC), a new antibiotic derived from ampicillin, has a broad spectrum and a bactericidal action. The authors investigated serum levels, urinary excretion, clinical effectiveness and untoward side effects of the agent. The results obtained are summarized as follows:
1. Following an oral administration of 250 mg Ampicillin and same dose Talampicillin in 3 healthy adult volunteers by crossover method, the mean serum levels of Talampicillin showed a peak of 2.66μg/ ml, 4 times as much as that of Ampicillin at 1-2 hours after administration, with 96.87 mg (38.7%) urinary excretion of Talampicillin within 6 hours.
2. Talampicillin was given on 37 patients with infections in the field of surgery, and the result was excellent in 12 cases, good 9, fair 11 and poor 5, the effectiveness rate accounting for 86.5%.
Nausea was observed in 2 cases and eruption in one case among 37 patients in trial.
