Kansenshogaku Zasshi
Online ISSN : 1884-569X
Print ISSN : 0387-5911
ISSN-L : 0387-5911
Clinical Study of Talampicillin (TAPC) in Urinary Tract Infections by Double-Blind Method
Jyoichi KUMAZAWA, Shunro MOMOSE, Nobuyuki ISHISAWA, Tetsuo OMOTO, Kohei SENOH, Zenjiro MASAKI, Toyofumi UEDA, Yukio OSADA, Eiji IWATSUBO, Motonori KANO, Hitonori KAMIZAKI, Haruka HIRANO, Tetsuro TAKESUE, Sadamu HIEDA, Masao OKUSU, Hiroshi KURAMOTO, Toru SHINKAWA, Asami ARIYOSHI, Kazuhiro OSHIMA, Yasuhito FUJISAWA, Yoshiharu HIRATSUKA, Seiji NAITO, Kimitaka SAKAMOTO, Kozo HIRATA, Ichikiro MORITA, Hideaki ITO, Yasuhiro OTA, Hiroyuki NAGAYOSHI, Seiichiro ANDO, Koichi OMARU, Ken NAKAYAMA, Seiichi NAKAMUTA, Hiroshi NAKAYAMA, Yonejiro KOKYO, Hiroshi HIRATA, Takuya AMANO, Hiroo YAGI, Sanshin HARA, Takahiko HARA, Kazushige NANRI, Akito YAMAGUCHI
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Keywords: Talampicillin, Ampicillin, Double-blind test, Urinary tract infection
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1975 Volume 49 Issue 11 Pages 440-457

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Abstract

Clinical usefulness of talampicillin (TAPC) was investigated in comparison with ampicillin (ABPC) under the double-blind test on patients with urinary tract infections, and following results were obtained.
1. Following 3 groups were categorized according to medication: TAPC 1g/day dosed group, TAPC 0.5g/day dosed group and ABPC 1g/day dosed group. All cases were medicated for 3 days.
2. Twenty-seven out of 226 cases were decided as dropout cases, and 199 cases were analyzed for evaluation of effectiveness.
3. Clinical improvements were observed in 87.9% on TAPC 1g group, 84.8% on TAPC 0.5g group and 83.6% on ABPC 1g group, respectively. There was no significant difference between each group statistically.
4. Significant correlations were observed between sensitivity to ABPC of urinary isolates and clinical improvements, and overall improvement of TAPC lg group was superior to TAPC 0.5g group, under examination with analysis of variance.
5. Under analysis of above method, between bacteriological improvement of urine and sensitivity to ABPC of isolated pathogens, significant correlations were found, and bacteriological improvement of TAPC 1g group in all pathogens isolated cases was superior to that of ABPC 1g group and to that of other two groups in E. coli isolated cases.
6. There were no differences in improvements of other clinical symptoms between each group.
7. Most of urinary isolates were E. coli (72.0%), and substituted infections were observed slightly more in TAPC 0.5g group, but differences between each group were not significant.
8. Gastrointestinal disturbance and skin rash were observed in 17 out of 214 cases, and no differences were found between each group, statistically.
9. From the results of this investigation, it is concluded that talampicillin is excellently effective for simple acute urinary tract infections, and its clinical and bacteriological value is identical with or rather better than equivalent dose of ampicillin.

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© The Japansese Association for Infectious Diseases
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