Abstract
The flat interface nerve electrode (FINE) is an alternative to cylindrical nerve cuffs for functional electrical stimulation (FES). By elongating the nerve in cross section, the FINE places more stimulating contacts around the nerve, and moves central axons closer to the electrode surface. Previous experiments have demonstrated that the FINE can activate selectively each fascicle in the cat sciatic nerve, and modeling studies have indicated that it should be possible to selectively activate groups of axons within individual fascicles. This hypothesis is tested using a combination of experimental and modeling techniques. Pairs of contacts stimulating the same fascicle were tested for subfascicle level selectivity, defined as the fraction of fibers activated by one contact but not by the other. It was possible to achieve greater than 90% selectivity with the FINE, but there was considerable variation in the results. The modeling studies showed that the selectivity achievable with a given contact pair depended strongly on the relative locations of the electrode and fascicle. Therefore, reshaping the cross section of a nerve can provide selectivity at the subfascicular level, but the electrode design must be optimized to improve selectivity across different nerve geometries. © 2003 Biomedical Engineering Society.
PAC2003: 8719Nn, 8717Nn, 8719La, 8780Xa
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References
Bagust, J.Relationships between motor nerve conduction velocities and motor unit contraction characteristics in a slow twitch muscle of the cat. J. Physiol.238:269–278, 1974.
Bowman, B. R., and R. C. D. Erickson. Acute and chronic implantation of coiled wire intraneural electrodes during cyclical electrical stimulation. Ann. Biomed. Eng.13:75–93, 1985.
Boyd, I. A., and M. R. Davey. Composition of Peripheral Nerves. Edinburgh: E & S Livingstone, 1968.
Branner, A., R. B. Stein, and R. A. Normann. Selective stimulation of cat sciatic nerve using an array of varying-length microelectrodes. J. Neurophysiol.85:1585–1594, 2001.
Choi, A. Q., J. K. Cavanaugh, and D. M. Durand. Selectivity of multiple-contact nerve cuff electrodes: A simulation analysis. IEEE Trans. Biomed. Eng.48:165–172, 2001.
Dengler, R., R. B. Stein, and C. K. Thomas. Axonal conduction velocity and force of single human motor units. Muscle Nerve11:136–145, 1988.
Goodall, E. V., J. F. De Breij, and J. Holsheimer. Position-selective activation of peripheral nerve fibers with a cuff electrode. IEEE Trans. Biomed. Eng.43:851–856, 1996.
Grill, W. M., and J. T. Mortimer. Noninvasive measurement of the input–output properties of peripheral nerve stimulating electrodes. J. Neurosci. Methods65:43–50, 1996.
Hursh, J. B.Conduction velocity and diameter of nerve fibers. Am. J. Physiol.127:131–139, 1939.
Jami, L., and J. Petit. Correlation between axonal conduction velocity and tetanic tension of motor units in four muscles of the cat hind limb. Brain Res.96:114–118, 1975.
Kernell, D., O. Eerbeek, and B. A. Verhey. Relation between isometric force and stimulus rate in cat's hindlimb motor units of different twitch contraction time. Exp. Brain Res.50:220–227, 1983.
Lundborg, G. Nerve Injury and Repair. Edinburgh, Scotland: Churchill Livingstone, 1988.
Meier, J. H., W. L. Rutten, and H. B. Boom. Force recruitment during electrical nerve stimulation with multipolar intrafascicular electrodes. Med. Biol. Eng. Comput.33:409–417, 1995.
Nannini, N., and K. Horch. Muscle recruitment with intrafascicular electrodes. IEEE Trans. Biomed. Eng.38:769–776, 1991.
Naples, G. G., J. T. Mortimer, A. Scheiner, and J. D. Sweeney. A spiral nerve cuff electrode for peripheral nerve stimulation (see comments). IEEE Trans. Biomed. Eng.35:905–916, 1988.
Proske, U., and P. M. Waite. The relation between tension and axonal conduction velocity for motor units in the medial gastrocnemius muscle of the cat. Exp. Brain Res.26:325–328, 1976.
Rutten, W. L., and J. H. Meier. Selectivity of intraneural prosthetic interfaces for muscular control. Med. Biol. Eng. Comput.29:NS3–NS7, 1991.
Rutten, W. L., H. J. Van Wier, and J. H. Put. Sensitivity and selectivity of intraneural stimulation using a silicon electrode array. IEEE Trans. Biomed. Eng.38:192–198, 1991.
Tyler, D. J. Functionally Selective Stimulation of Peripheral Nerves: Electrodes That Alter Nerve Geometry. Cleveland, OH: Case Western Reserve University, 1999.
Tyler, D. J., and D. M. Durand. Functionally selective peripheral nerve stimulation with a flat interface nerve electrode, (in press).
Veltink, P. H., J. A. Van Alste, and H. B. Boom. Multielectrode intrafascicular and extraneural stimulation. Med. Biol. Eng. Comput.27:19–24, 1989.
Yoshida, K., and K. Horch. Reduced fatigue in electrically stimulated muscle using dual channel intrafascicular electrodes with interleaved stimulation. Ann. Biomed. Eng.21:709–714, 1993.
Yoshida, K.and K. Horch. Selective stimulation of peripheral nerve fibers using dual intrafascicular electrodes. IEEE Trans. Biomed. Eng.40:492–494, 1993.
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Leventhal, D.K., Durand, D.M. Subfascicle Stimulation Selectivity with the Flat Interface Nerve Electrode. Annals of Biomedical Engineering 31, 643–652 (2003). https://doi.org/10.1114/1.1569266
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DOI: https://doi.org/10.1114/1.1569266