Abstract
In the present paper, we overview the discovery of new biological activities induced by ginsenoside Rg1 and Rb1 and discuss possible mechanisms of action. Both compounds could increase neural plasticity in efficacy and structure; especially Rg1, as one small molecular drug, can increase proliferation and differentiation of neural progenitor cells in dentate gyrus of hippocampus of normal adult mice and global ischemia model in gerbils. This finding has great value for treatment of Alzheimer's disease and other neurodegenerative disorders which is characterized by neurons loss. Increase of expression of brain derived neurotrophic factor, Bcl-2 and antioxidant enzyme, enhanced new synapse formation, inhibition of apoptosis and calcium overload are also important neuron protective factors. Rg1 and Rb1 have common effects, but there are some differences in pharmacology and mechanism. These differences may attribute to their different chemical structure. Rg1 is panaxtriol with two sugars, while Rb1 is panaxtriol with four sugars.
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Chang SY, Kuang PG, Zhang JT, Chen YY, Yu CM . Memory facilitation induced by gynostemma, pentaphyllum and gypensode III (ginsenoside b1) in mice. Chin Pharmacol Bull 1988; 4: 358–61.
Zhang JT, Qu ZW, Liu Y, Deng HL . Preliminary study on antiamnestic mechanism of ginsenoside Rg1 and Rb1. Chin Med J 1990; 103: 932–8.
Qiu Y, Du GH, Qu ZW, Zhang JT . Protective effects of ginsenoside on the learning and memory impairment induced by transient cerebral ischemia-reperfusion in mice. Chin Pharmacol Bull 1995; 11: 299–302.
Zhang DS, Zhang JT . Effects of total ginsenoside on learning and memory impairment induced by beta-amyloid peptide (25-35). Chin Pharmacol Bull 2000; 16: 422–5.
Wang XY, Zhang JT . Effects of ginenoside Rg1 on learning and memory impairment induced by β-amyloid peptide (25-35) and its mechanism of action. Acta Pharm Sin 2001; 36: 1–4.
Mook-Jung I, Hong HS, Boo JH, Lee KH, Yun SH, Cheong MY, et al. Ginsenoside Rb1 and Rg1 improve spatial learning and increase hippocampal synaptophysin level in mice. J Neurosci Res 2001; 63: 509–15.
Chen J, Gong YS, Zhang JT . Effects of 17 estradiol and total ginsenoside on the spatial learning and memory impairment of ovariectomy rats. Chin Pharm J 2001; 36: 522–6.
Zhang DS, Zhang JT . Effect of total ginsenoside on synaptic transmission in dentate gyrus in rats. Acta Pharm Sin 2000; 35: 185–8.
Wang XY, Zhang JT . NO mediates ginsenoside Rg1-induced long-term potentiation in anesthetized rats. Acta Pharmacol Sin 2001; 22: 657–62.
Wang XY, Zhang JT . Effect of ginsenoside Rb1 on long-term potentiation in the dentate gyrus of anaesthetized rats. J Asian Nat Prod Res 2003; 5: 1–4.
Wang XY, Zhang JT . Effects of ginsenoside Rg1 on synaptic plasticity of freely moving rats and its mechanism of action. Acta Pharmacol Sin 2001; 22: 1099–102.
Zhang JT, Liu Y, Qu, ZhW, Zhang, XL, Xiao HL . Influence of ginsenoside Rb1 and Rg1 on some central neurotransmitter receptors and protein biosynthesis in mouse brain. Acta Pharm Sin 1988; 23: 12–6.
Banishin CG, Liu HJ, Wang LCH, Pang PKT . Ginsenosides Rb1 and Rg1 increase central nervous system cholinergic metabolism. In: Shojishibata et al editors. Recent advances in ginseng studies. Tokyo: Hirokawa Publishing Company 1989; 139–43.
Burgen ASV . Regulation of acetylcholine receptors. In: Yoshida, H, et al, eds. Advances in pharmacology and therapeutics: II. Neurotransmitters receptors. Tokyo: Pergamon press 1981; 51–2.
Liu M, Zhang JT . Influence of ginsenoside Rb1 and Rg1 on some central neurotransmitter receptors and protein biosynthesis in mouse brain. Acta Pharmacol Sin 1996; 17: 171–4.
Li JQ, Zhang XG, Zhang JT . Inhibition of apoptosis by ginsenoside Rg1 in cultured cortical neurons. Acta Pharm Sin 1997; 32: 406–10.
Li JQ, Li ZK, Duan H, Zhang JT . Effect of age and ginsenoside Rg1 on nitric oxide content and nitric oxide synthase activity of cerebral cortex on rats. Acta Pharm Sin 1997; 32: 251–4.
Chen XC, Chen Y, Zhu YG, Fang F, Chen LM . Protecive effect of ginsenoside Rg1 against MPTP-induced apoptosis in mouse substantia nigra neurons. Acta Pharmacol Sin 2002; 23: 829–34.
Chen XC, Zhu YG, Wang XZ, Zhu LA, Huang C . Protective effect of ginsenoside Rg1 on dopamine-induced apoptosis in PC12 cells. Acta Pharmacol Sin 2001; 22: 673–8.
Yang Y, Zhang JT, Shi CZ, Qu ZW, Liu Y . Study on the nootropic mechanism of ginsenoside Rb1 and Rg1 influence on mouse brain development. Acta Pharm Sin 1994; 29: 241–5.
Mook-Jung I, Hong HS, Boo JH, Lee KH, Yun SH, Cheong MY, et al. Ginsenoside Rb1 and Rg1 improve spatial learning and increase hippocampal synaptophysin level in mice. J Neurosci Res 2001; 63: 509–15
Gage, FH . Mammalian neural stem cells. Science 2000; 287: 1433–8.
Kuhn HG, Dickinson-Anson H, Gage FH . Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J Neurosci 1996; 16: 2027–33.
Shors TJ, Miesegaes G, Beylin A, Zhao M, Rydel T, Gould E . Neurogenesis in the adult is involved in the formation of trace memories. Nature 2001; 410: 372–6.
Haughey NJ, Liu D, Nath A, Borchard AC, Mattson MP . Disruption of neurogenesis in the subventricular zone of adult mice, and in human cortical neuronal precursor cells in culture, by amyloid betapeptide: implications for the pathogenesis of Alzheimer's disease. Neuromolecular Med 2002; 1: 125–35.
Shen LH, Zhang JT . Ginsenoside Rg1 promotes proliferation of hippocampal progenitor cells. Neurol Res 2004; 26: 422–8.
Shen LH, Zhang JT . Ginsenoside Rg1 increases ischemia-induced cell proliferation and survival in the dentate gyrus of adult gerbils. Neurosci Lett 2003; 344: 1–4.
Lian XY, Zhang JT . Effect of ginsenoside Rb1 on repeated stress-induced sexual deficiencies in male mice. Acta Pharm Sin 1998; 33: 184–7.
Wang XY, Zhang JT . Effect of ginsenoside Rb1 on mouse sexual function and its mechanism. Acta Pharm Sin 2002; 35: 492–5.
Lian XY, Zhang JT . Chronic stress and gonadectomy decrease the levels of neurotrophin-3 and brain-derived neurotrophic factor in adult mouse brain. Chin J Pharmacol Toxicol 2001; 15: 245–50.
Liu M, Zhang JT . The immunoregulatory effects of ginsenoside Rg1 in aged rats. Acta Pharm Sin 1995; 30: 818–23.
Liu M, Zhang JT . Studies on the mechanisms of immunoregulatory effects of ginsenoside Rg1 in aged rats. Acta Pharm Sin 1996; 31: 95–100.
Chan RY, Chen WF, Dong A, Guo D, Wong MS . Estrogen-like activity of ginsenoside Rg1 derived from Panax notoginseng. J Clin Endocrinol Metab 2002; 87: 3691–5.
Teng CM, Kuo SC, Ko FN, Lee JC, Lee LG, Chen SC, et al. Antiplatelet actions of panaxynol and ginsenosides isolated from ginseng. Biochim Biophys Acta 1989; 990: 315–20.
Kimura Y, Okuda H, Arichi S . Effects of various ginseng saponins on 5-hydroxytryptamine release and aggregation in human platelets. J Pharm Pharmacol 1988; 40: 838–43.
Wu W, Zhang XM, Liu PM, Li JM, Wang JF . Effects of Panax notoginseng saponin Rg1 on cardiac electrophysiological properties and ventricular fibrillation threshold in dogs. Acta Pharmacol Sin 1995; 16: 459–63.
Park KH, Shin HJ, Song YB, Hyun HC, Cho HJ, Ham HS, et al. Possible role of ginsenoside Rb1 on regulation of rat liver triglycerides. Biol Pharm Bull 2002; 25: 457–60.
Ota T, Maeda M, Odashima S, Ninomiya-Tsuji J, Tatsuka M . G1 phase-specific suppression of the Cdk2 activity by ginsenoside Rh2 in cultured murine cells. Life Sci 1997; 60: PL39–44.
Han R . Highlight on the studies of anticancer drugs derived from plants in China. Stem Cells 2002; 12: 53–63.
Zhang JT . The retrospection and prospect of ginseng research. Acta Pharm Sin 1995; 30: 321–5.
Dou DQ, Jin L, Chen YJ . Advances and prospects of the study on chmical constituents and pharmacological activities of Panax ginseng. J Shenyang Pharm Univ 1999; 16: 151–6.
Huang YS, Liu Y, Qu ZW, Zhang JT . Effect of ginsenoside Rb1 and Rg1 on lipid peroxidation of rat in vitro. Acta Acad Med Sin 1989; 11: 460–2.
Deng HL, Zhang JT . Anti-lipid peroxydative effect of ginsenoside Rb1 and Rg1. Chin Med J 1991; 104: 395–8.
Liu M, Zhang JT . Effects of ginsenoside Rb1 and Rg1 on synaptosomal free calcium level, ATPase and calmudulin in rat hippocampus. Chin Med J 1995; 108: 544–7.
Jiang XY, Zhang JT, Shi CZ . Mechanism of action of ginsenoside Rb1 in decreasing intracellular Ca2+. Acta Pharm Sin 1996; 31: 321–6.
Liu M, Zhang JT . Protective effects of ginsenoside Rb1 and Rg1 in cultured hippocampal neurons. Acta Pharm Sin 1995; 30: 674–8.
Wang JH, Li W, Sha Y, Tezuka Y, Kadota S, Li X . Triterpenoid saponins from leaves and stems of Panax quinquefolium L. J Asian Nat Prod Res 2001; 3: 293–7.
Yang XW, Li LY, Tian JM, Zhang ZW, Ye JM, Gu WF . Ginsenoside-Rg6, a novel triterpenoid saponin from the stem-leaves of Panax ginseng CAMey. Chin Chem Lett 2000; 11: 909–12.
Le TO, Quan LT, Adnyana IK, Yasuhiro Tezuka, Nagaoka, T, Qui KT, et al. Triterpene saponins from Vietnamese Ginseng (Panax vietnamensis) and their hepatocytoprotective activities. J Nat Prod 2001; 64: 456–61.
Dou DQ, Chen YJ, Liang LH, Pang FG, Shimizu N, Takeda T . Six new dammarane-type triterpene saponins from the leaves of Panax ginseng. Chem Pharm Bull 2001; 49: 442–6.
Park JD, Lee YH, Kim SI . Ginsenoside Rf2, a new dammarane glycoside from Korean red ginseng (Panax ginseng). Arch Pharm Res 1998; 21: 615–7.
Qiu F, Ma ZZ, Pei YP, Xu SX, Yao XS, Chen YT, et al. A new dammarane glycoside from the flower-buds of Panax ginseng CA Meyer. Chin Chem Lett 1998; 9: 643–5.
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Cheng, Y., Shen, Lh. & Zhang, Jt. Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action. Acta Pharmacol Sin 26, 143–149 (2005). https://doi.org/10.1111/j.1745-7254.2005.00034.x
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DOI: https://doi.org/10.1111/j.1745-7254.2005.00034.x
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