ORIGINAL ARTICLEBMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density culture
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3D bioprinting of cartilaginous templates for large bone defect healing
2023, Acta BiomaterialiaDual non-viral gene delivery from microparticles within 3D high-density stem cell constructs for enhanced bone tissue engineering
2018, BiomaterialsCitation Excerpt :Importantly, stem cell condensations have been shown to undergo both chondrogenic and osteogenic differentiation [13–18], typically through the addition of specific proteins in the culture medium. GFs of the transforming growth factor-β (TGF-β) family, such as TGF-β1, have been used for chondrogenesis [13,19] and bone morphogenetic proteins (BMPs), such as BMP-2, have been used for both chondrogenesis and osteogenesis [20–22]. In particular, BMP-2 has been shown to promote chondrocyte proliferation and hypertrophy, an integral step in endochondral ossification [23], one of two bone formation pathways that occur during native long bone formation and fracture healing.
Signaling Pathways in Trans-differentiation of Mesenchymal Stem Cells: Recent Advances
2024, Methods in Molecular Biology
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