ORIGINAL ARTICLE
Posttraumatic stress and medication adherence in pediatric transplant recipients

https://doi.org/10.1111/ajt.16896Get rights and content
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Adolescent transplant recipients may encounter a range of potentially traumatic events (PTEs) pre- and posttransplant, yet little is known about the relationship between posttraumatic stress symptoms (PTSS) and medication adherence in this population. In the present study, adolescent recipients and caregivers completed psychosocial questionnaires at enrollment. Outpatient tacrolimus trough level data were collected over 1 year to calculate the Medication Level Variability Index (MLVI), a measure of medication adherence. Nonadherence (MLVI ≥2) was identified in 34.8% of patients, and most (80.7%) reported ≥1 PTE exposure. Levels of PTSS indicating likely posttraumatic stress disorder (PTSD) were endorsed by 9.2% of patients and 43.7% of caregivers. PTSS and MLVI were significantly correlated in the liver subgroup (r = .30, p = .04). Hierarchical multivariable linear regression analyses revealed overall patient PTSS were significantly associated with QoL (p < .001). PTEs are common in adolescent recipients; a minority may meet criteria for PTSD. PTSS screening to identify nonadherence risk requires further investigation and addressing PTSS may improve QoL. Caregivers appear at greater risk for PTSD and may require their own supports. The study was approved by each participating center’s Institutional Review Board.

KEYWORDS

clinical research/practice
compliance/adherence
mental health
pediatrics
quality of life (QOL)
social sciences

Abbreviations

CDI-S
Children’s Depression Inventory, Short Form
CoV
coefficient of variation
CTOTC
Clinical Trials in Organ Transplantation in Children consortium
IES
Impact of Event Scale
MLVI
Medication Level Variability Index
PTE
potentially traumatic event
PTSD
posttraumatic stress disorder
PTSDRI
UCLA Posttraumatic Stress Disorder Reaction Index
PTSS
posttraumatic stress symptoms
QoL
quality of life
SOT
solid organ transplant

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