Original ArticleTCR Repertoire Analysis by Next Generation Sequencing Allows Complex Differential Diagnosis of T Cell–Related Pathology
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Key words:
Acute cellular rejection
BKV
differential diagnosis
kidney transplantation
next generation sequencing
polyoma
Abbreviations
ACR
acute cellular rejection
BKV
polyomavirus BK
BKVAN
BKV-associated nephropathy
CDR3
complementarity determining region 3
CMCV
cumulative mean CV
CMV
cytomegalovirus
CV
coefficient of variation
gDNA
genomic DNA
MH
Morisita–Horn similarity index
NGS
next generation sequencing
OPP
overlapping peptide pools
PBMC
peripheral blood mononuclear cells
PCR
polymerase chain reaction
TCR
T cell receptor
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These authors contributed equally.
Copyright © 2013 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.