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Selective laser sintering manufacturing of polycaprolactone bone scaffolds for applications in bone tissue engineering

Alida Mazzoli (Department of Scienze e Ingegneria della Materia, Università Politecnica delle Marche, Ancona, Italy)
C Ferretti (Department of Clinical and Molecular Sciences, Università Politecnica delle March, Ancona, Italy.)
A Gigante (Department of Clinical and Molecular Sciences, Università Politecnica delle March, Ancona, Italy.)
E Salvolini (Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.)
M Mattioli-Belmonte (Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.)

Rapid Prototyping Journal

ISSN: 1355-2546

Article publication date: 15 June 2015

916

Abstract

Purpose

The purpose of this study is to show how selective laser sintering (SLS) manufacturing of bioresorbable scaffolds is used for applications in bone tissue engineering.

Design/methodology/approach

Polycaprolactone (PCL) scaffolds were computationally designed and then fabricated via SLS for applications in bone and cartilage repair.

Findings

Preliminary biocompatibility data were acquired using human mesenchymal stem cells (hMSCs) assuring a satisfactory scaffold colonization by hMSCs.

Originality/value

A promising procedure for producing porous scaffolds for the repair of skeletal defects, in tissue engineering applications, was developed.

Keywords

Citation

Mazzoli, A., Ferretti, C., Gigante, A., Salvolini, E. and Mattioli-Belmonte, M. (2015), "Selective laser sintering manufacturing of polycaprolactone bone scaffolds for applications in bone tissue engineering", Rapid Prototyping Journal, Vol. 21 No. 4, pp. 386-392. https://doi.org/10.1108/RPJ-04-2013-0040

Publisher

:

Emerald Group Publishing Limited

Copyright © 2015, Emerald Group Publishing Limited

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