Healthy eating index-2015 and breast cancer: a case-control study

Recently, evidences have suggested that healthy eating index (HEI), an index-based dietary pattern, may be a predictor for the risk of cancer. This paper aims to examine the association of HEI-2015 and its all components scores with the risk of breast cancer (BC), separately, among Iranian women.

In the present hospital-based, case-control study, 150 age-matched of cases (newly diagnosed female) and 150 controls were recruited. Data of dietary habits and anthropometric measures were obtained, and eventually, the HEI-2015 score was calculated. Multivariate odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the relationship between the risk of BC across tertiles (Ts) of total HEI-2015 and its all component scores.

The results presented that in adjusted model, there was no significant difference between total HEI-2015 (p = 0.14) and its all component scores (p > 0.09) of healthy subjects and females with BC. Moreover, multivariable logistic regression analyses indicated that HEI-2015 score was not associated with the risk of BC in either crude (p-trend = 0.94) or adjusted (p-trend = 0.73) analyses. In the analyses of HEI-2015 components scores, it was observed that the scores of grains (OR, 0.53; 95% CI, 0.30–0.94) and total protein foods (OR, 0.13; 95% CI, 0.02–0.58) may have a relation with BC risk in crude model but after adjusting for BC risk factors, the mentioned associations changed to non-significant.

The findings of current study suggested that there was no significant association of total HEI-2015 and its components scores, independently, with BC incidence among Iranian women.