Supporting information
Crystallographic Information File (CIF) https://doi.org/10.1107/S1600536803011012/cv6194sup1.cif | |
Structure factor file (CIF format) https://doi.org/10.1107/S1600536803011012/cv6194Isup2.hkl |
CCDC reference: 214856
A mixture of 4-(4-methoxybenzoyl)-2-[(Z)-methoxycarbonylmethylene]-5- (4-methoxyphenyl)-2,3-dihydro-3-furanone (2.213 g, 5 mmol) and o-toluidine (0.536 g, 5 mmol) in dry benzene (25 ml) was refluxed for 0.5 h. The solid obtained after evaporation of the solvent was recrytstallized from ethanol to give yellow crystals of 2(R)-hydroxy-4-(4-methoxybenzoyl)-2- methoxycarbonylmethyl-5-(4-methoxyphenyl)-1-(2-methylphenyl)-2,3-dihydro- 1H-3-pyrrolone; yield: 1.574 g (59%), m.p: 442 K. Solvents were dried by refluxing with the appropriate drying agent and distilled before use. Melting points were determined on an Electrothermal 9200 apparatus and were uncorrected. Elemental analysis was performed with a Carlo Erba Elemental Analyzer 1108. An FT–IR spectrum was measured on a Jasco-Plus Model 460 spectrometer, using a potassium bromide pellet. The 1H and 13C NMR spectra were recorded on a Gemini-Varian 200 MHz instrument. The chemical shifts are reported in p.p.m. from tetramethylsilane and given in d units. FT–IR (KBr, cm−1): ν = 3200.29 (broad OH), 1740.92 (C20═O), 1653.66 (C22═O), 1633.41 (C2═O), 1257.84 (C20—O4—C21); 1H NMR (CDCl3, p.p.m.): δ = 2.181 (s, 3H, Ph—CH3), 2.806–3.081 (q, 2H, CH2), 3.528, 3.666, 3.813 (s, 9H, OCH3), 5.901 (s, 1H, OH), 6.885–7.942 (m, 12H, Ar—H); 13C NMR (CDCl3, p.p.m.): δ = 20.895 (C18), 41.927 (C19), 54.230, 57.180, 57.384 (C21, C29 and C11), 92.432 (C1), 110.032–165.105 (C═C, aromatic and aliphatic), 181.055 (C20═O), 190.213 (C22═O), 198.213 (C2═O). Analysis calculated for C31H35NO7: C 69.78, N 2.62, H 6.61%; found: C 69.65, N 2.56, H 6.59%.
All H atoms were placed in geometrically idealized positions and constrained to ride on their parent atoms.
Data collection: SMART (Siemens, 1996); cell refinement: SAINT (Siemens, 1996); data reduction: SAINT; program(s) used to solve structure: SIR97 (Altomare et al., 1999); program(s) used to refine structure: SHELXL97 (Sheldrick, 1997); molecular graphics: ORTEP-3 for Windows (Farrugia, 1997); software used to prepare material for publication: PARST (Nardelli, 1995) and WinGX (Farrugia, 1999).
Fig. 1. An ORTEP drawing of (I), showing the labelling of the non-H atoms. Displacement ellipsoids are shown at the 10% probability level. |
C29H27NO7 | Z = 2 |
Mr = 501.52 | F(000) = 528 |
Triclinic, P1 | Dx = 1.287 Mg m−3 |
Hall symbol: -P 1 | Mo Kα radiation, λ = 0.71073 Å |
a = 8.948 (5) Å | Cell parameters from 2345 reflections |
b = 11.254 (5) Å | θ = 5.7–53.7° |
c = 13.724 (5) Å | µ = 0.09 mm−1 |
α = 110.167 (5)° | T = 293 K |
β = 93.755 (5)° | Block, yellow |
γ = 90.106 (5)° | 0.28 × 0.24 × 0.18 mm |
V = 1294.1 (10) Å3 |
Siemens SMART CCD area-detector diffractometer | 5384 independent reflections |
Radiation source: fine-focus sealed tube | 2742 reflections with I > 2σ(I) |
Graphite monochromator | Rint = 0.000 |
Detector resolution: 8.33 pixels mm-1 | θmax = 27.3°, θmin = 2.9° |
ω scans | h = −11→11 |
Absorption correction: part of the refinement model (ΔF) (Parkin et al., 1995) Cubic fit to sin(theta)/lambda - 24 parameters | k = −15→14 |
Tmin = 0.975, Tmax = 0.984 | l = 0→18 |
5384 measured reflections |
Refinement on F2 | Primary atom site location: structure-invariant direct methods |
Least-squares matrix: full | Secondary atom site location: difference Fourier map |
R[F2 > 2σ(F2)] = 0.078 | Hydrogen site location: inferred from neighbouring sites |
wR(F2) = 0.257 | H atoms treated by a mixture of independent and constrained refinement |
S = 1.00 | w = 1/[σ2(Fo2) + (0.1411P)2] where P = (Fo2 + 2Fc2)/3 |
5384 reflections | (Δ/σ)max < 0.001 |
322 parameters | Δρmax = 0.54 e Å−3 |
1 restraint | Δρmin = −0.29 e Å−3 |
C29H27NO7 | γ = 90.106 (5)° |
Mr = 501.52 | V = 1294.1 (10) Å3 |
Triclinic, P1 | Z = 2 |
a = 8.948 (5) Å | Mo Kα radiation |
b = 11.254 (5) Å | µ = 0.09 mm−1 |
c = 13.724 (5) Å | T = 293 K |
α = 110.167 (5)° | 0.28 × 0.24 × 0.18 mm |
β = 93.755 (5)° |
Siemens SMART CCD area-detector diffractometer | 5384 independent reflections |
Absorption correction: part of the refinement model (ΔF) (Parkin et al., 1995) Cubic fit to sin(theta)/lambda - 24 parameters | 2742 reflections with I > 2σ(I) |
Tmin = 0.975, Tmax = 0.984 | Rint = 0.000 |
5384 measured reflections |
R[F2 > 2σ(F2)] = 0.078 | 1 restraint |
wR(F2) = 0.257 | H atoms treated by a mixture of independent and constrained refinement |
S = 1.00 | Δρmax = 0.54 e Å−3 |
5384 reflections | Δρmin = −0.29 e Å−3 |
322 parameters |
Geometry. Bond distances, angles etc. have been calculated using the rounded fractional coordinates. All e.s.d.'s are estimated from the variances of the (full) variance-covariance matrix. The cell e.s.d.'s are taken into account in the estimation of distances, angles and torsion angles |
Refinement. Refinement on F2 for ALL reflections except those flagged by the user for potential systematic errors. Weighted R-factors wR and all goodnesses of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The observed criterion of F2 > σ(F2) is used only for calculating -R-factor-obs etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R-factors based on ALL data will be even larger. |
x | y | z | Uiso*/Ueq | ||
O1 | 0.4380 (3) | 0.1806 (2) | 0.57598 (17) | 0.0594 (7) | |
O2 | 0.6063 (3) | −0.0214 (2) | 0.62095 (18) | 0.0609 (8) | |
O3 | 0.9095 (3) | 0.1478 (4) | 0.6198 (2) | 0.0851 (13) | |
O4 | 0.9314 (4) | 0.2001 (4) | 0.4803 (2) | 0.0956 (13) | |
O5 | 0.5549 (4) | 0.1283 (3) | 0.9223 (2) | 0.0759 (10) | |
O6 | 1.1126 (4) | −0.2202 (3) | 0.8827 (3) | 0.0909 (14) | |
O7 | 0.8319 (4) | 0.6700 (3) | 1.1684 (2) | 0.0872 (10) | |
N1 | 0.6171 (3) | 0.3129 (2) | 0.6995 (2) | 0.0532 (9) | |
C1 | 0.5905 (4) | 0.1902 (3) | 0.6125 (2) | 0.0509 (9) | |
C2 | 0.6190 (4) | 0.0935 (3) | 0.6682 (2) | 0.0492 (9) | |
C3 | 0.6448 (4) | 0.1610 (3) | 0.7752 (2) | 0.0481 (9) | |
C4 | 0.6473 (4) | 0.2898 (3) | 0.7890 (2) | 0.0473 (9) | |
C5 | 0.6877 (4) | 0.3936 (3) | 0.8873 (2) | 0.0500 (9) | |
C6 | 0.7961 (5) | 0.3705 (3) | 0.9576 (3) | 0.0647 (13) | |
C7 | 0.8401 (6) | 0.4645 (4) | 1.0482 (3) | 0.0776 (14) | |
C8 | 0.7784 (5) | 0.5837 (3) | 1.0753 (3) | 0.0639 (13) | |
C9 | 0.6704 (5) | 0.6073 (3) | 1.0085 (3) | 0.0585 (10) | |
C10 | 0.6255 (4) | 0.5121 (3) | 0.9140 (2) | 0.0519 (9) | |
C11 | 0.7722 (5) | 0.7913 (4) | 1.2006 (3) | 0.0764 (14) | |
C12 | 0.6365 (5) | 0.4284 (3) | 0.6823 (3) | 0.0798 (16) | |
C13 | 0.7814 (5) | 0.4788 (5) | 0.6952 (4) | 0.179 (5) | |
C14 | 0.8067 (10) | 0.5951 (6) | 0.6839 (5) | 0.343 (14) | |
C15 | 0.6871 (13) | 0.6611 (4) | 0.6598 (5) | 0.37 (2) | |
C16 | 0.5422 (11) | 0.6107 (5) | 0.6470 (4) | 0.307 (14) | |
C17 | 0.5169 (6) | 0.4944 (5) | 0.6582 (3) | 0.132 (3) | |
C18 | 0.3560 (19) | 0.4519 (14) | 0.6478 (12) | 0.272 (12) | |
C19 | 0.6885 (4) | 0.1750 (3) | 0.5223 (2) | 0.0566 (10) | |
C20 | 0.8530 (4) | 0.1734 (4) | 0.5485 (3) | 0.0601 (11) | |
C21 | 1.0921 (6) | 0.1952 (8) | 0.4957 (5) | 0.121 (3) | |
C22 | 0.6474 (4) | 0.1019 (3) | 0.8568 (2) | 0.0550 (10) | |
C23 | 0.7651 (4) | 0.0096 (3) | 0.8561 (2) | 0.0545 (10) | |
C24 | 0.8909 (4) | 0.0055 (3) | 0.8011 (3) | 0.0579 (11) | |
C25 | 1.0093 (5) | −0.0709 (4) | 0.8072 (3) | 0.0669 (12) | |
C26 | 1.0018 (5) | −0.1450 (3) | 0.8697 (3) | 0.0673 (13) | |
C27 | 0.8756 (6) | −0.1441 (3) | 0.9221 (3) | 0.0715 (14) | |
C28 | 0.7586 (5) | −0.0668 (3) | 0.9172 (3) | 0.0657 (13) | |
C29 | 1.2501 (8) | −0.2163 (7) | 0.8393 (4) | 0.116 (3) | |
H1 | 0.42020 | 0.11070 | 0.53160 | 0.0890* | |
H6 | 0.83750 | 0.29090 | 0.94200 | 0.0770* | |
H7 | 0.91340 | 0.44860 | 1.09310 | 0.0930* | |
H9 | 0.62730 | 0.68640 | 1.02610 | 0.0700* | |
H10 | 0.55330 | 0.52860 | 0.86870 | 0.0620* | |
H11A | 0.81980 | 0.84130 | 1.26690 | 0.1140* | |
H11B | 0.66650 | 0.78490 | 1.20660 | 0.1140* | |
H11C | 0.78950 | 0.83080 | 1.15040 | 0.1140* | |
H13 | 0.86140 | 0.43470 | 0.71130 | 0.2150* | |
H14 | 0.90360 | 0.62880 | 0.69250 | 0.4120* | |
H15 | 0.70400 | 0.73890 | 0.65220 | 0.4430* | |
H16 | 0.46210 | 0.65490 | 0.63080 | 0.3690* | |
H18A | 0.34970 | 0.37270 | 0.65950 | 0.4090* | |
H18B | 0.31400 | 0.44130 | 0.57910 | 0.4090* | |
H18C | 0.30140 | 0.51430 | 0.69810 | 0.4090* | |
H19A | 0.65910 | 0.09660 | 0.46650 | 0.0680* | |
H19B | 0.66910 | 0.24380 | 0.49630 | 0.0680* | |
H21A | 1.13860 | 0.21820 | 0.44340 | 0.1810* | |
H21B | 1.11940 | 0.11090 | 0.49060 | 0.1810* | |
H21C | 1.12510 | 0.25330 | 0.56340 | 0.1810* | |
H24 | 0.89570 | 0.05520 | 0.75940 | 0.0690* | |
H25 | 1.09300 | −0.07290 | 0.76990 | 0.0800* | |
H27 | 0.86930 | −0.19660 | 0.96130 | 0.0860* | |
H28 | 0.67510 | −0.06540 | 0.95450 | 0.0790* | |
H29A | 1.31750 | −0.27420 | 0.85560 | 0.1730* | |
H29B | 1.29290 | −0.13210 | 0.86760 | 0.1730* | |
H29C | 1.23370 | −0.24010 | 0.76510 | 0.1730* |
U11 | U22 | U33 | U12 | U13 | U23 | |
O1 | 0.0419 (12) | 0.0648 (14) | 0.0618 (12) | 0.0016 (10) | −0.0037 (9) | 0.0107 (10) |
O2 | 0.0673 (16) | 0.0490 (12) | 0.0595 (12) | −0.0034 (11) | −0.0053 (10) | 0.0119 (10) |
O3 | 0.0528 (16) | 0.136 (3) | 0.0833 (17) | −0.0038 (17) | 0.0016 (13) | 0.0600 (19) |
O4 | 0.0595 (18) | 0.156 (3) | 0.0871 (19) | −0.0088 (19) | 0.0128 (14) | 0.061 (2) |
O5 | 0.083 (2) | 0.0806 (18) | 0.0761 (16) | 0.0196 (15) | 0.0295 (14) | 0.0379 (14) |
O6 | 0.105 (3) | 0.0781 (19) | 0.096 (2) | 0.0341 (18) | 0.0042 (18) | 0.0386 (17) |
O7 | 0.108 (2) | 0.0663 (17) | 0.0661 (15) | 0.0011 (16) | −0.0221 (15) | 0.0010 (13) |
N1 | 0.0563 (17) | 0.0504 (14) | 0.0506 (13) | −0.0053 (12) | −0.0005 (11) | 0.0152 (11) |
C1 | 0.0427 (16) | 0.0548 (16) | 0.0494 (14) | −0.0060 (13) | −0.0045 (12) | 0.0122 (12) |
C2 | 0.0404 (16) | 0.0503 (15) | 0.0535 (14) | 0.0017 (12) | 0.0024 (12) | 0.0139 (12) |
C3 | 0.0489 (17) | 0.0445 (14) | 0.0496 (14) | −0.0006 (12) | 0.0059 (12) | 0.0142 (12) |
C4 | 0.0449 (17) | 0.0498 (15) | 0.0479 (13) | −0.0027 (13) | 0.0051 (11) | 0.0173 (12) |
C5 | 0.0530 (18) | 0.0471 (15) | 0.0481 (14) | −0.0057 (13) | 0.0037 (12) | 0.0140 (12) |
C6 | 0.075 (3) | 0.0508 (17) | 0.0612 (18) | 0.0028 (17) | −0.0086 (16) | 0.0127 (14) |
C7 | 0.093 (3) | 0.067 (2) | 0.062 (2) | 0.002 (2) | −0.0184 (19) | 0.0128 (17) |
C8 | 0.075 (3) | 0.0525 (18) | 0.0591 (18) | −0.0093 (17) | 0.0030 (16) | 0.0132 (15) |
C9 | 0.071 (2) | 0.0453 (15) | 0.0603 (17) | −0.0029 (15) | 0.0112 (15) | 0.0184 (13) |
C10 | 0.0573 (19) | 0.0450 (14) | 0.0523 (15) | −0.0023 (13) | 0.0010 (13) | 0.0159 (12) |
C11 | 0.084 (3) | 0.065 (2) | 0.062 (2) | −0.010 (2) | 0.0057 (18) | −0.0011 (16) |
C12 | 0.123 (4) | 0.059 (2) | 0.059 (2) | −0.018 (2) | 0.011 (2) | 0.0216 (17) |
C13 | 0.284 (12) | 0.142 (6) | 0.086 (4) | −0.112 (7) | 0.077 (5) | −0.005 (4) |
C14 | 0.61 (4) | 0.223 (13) | 0.139 (8) | −0.280 (19) | 0.113 (14) | −0.026 (9) |
C15 | 0.83 (6) | 0.172 (12) | 0.126 (9) | −0.02 (2) | 0.122 (19) | 0.059 (9) |
C16 | 0.70 (4) | 0.149 (9) | 0.109 (6) | 0.184 (18) | 0.131 (13) | 0.071 (7) |
C17 | 0.223 (9) | 0.098 (4) | 0.080 (3) | 0.053 (5) | 0.025 (4) | 0.036 (3) |
C18 | 0.37 (3) | 0.215 (13) | 0.211 (14) | 0.079 (15) | −0.034 (15) | 0.057 (11) |
C19 | 0.0533 (19) | 0.0662 (19) | 0.0510 (15) | −0.0006 (15) | 0.0027 (13) | 0.0213 (14) |
C20 | 0.051 (2) | 0.073 (2) | 0.0582 (17) | −0.0021 (16) | 0.0108 (14) | 0.0240 (16) |
C21 | 0.061 (3) | 0.195 (7) | 0.132 (5) | −0.002 (4) | 0.026 (3) | 0.086 (5) |
C22 | 0.064 (2) | 0.0459 (15) | 0.0535 (15) | −0.0033 (14) | 0.0045 (14) | 0.0152 (13) |
C23 | 0.067 (2) | 0.0456 (15) | 0.0506 (15) | −0.0004 (14) | 0.0022 (14) | 0.0165 (12) |
C24 | 0.058 (2) | 0.0580 (18) | 0.0630 (17) | 0.0027 (15) | 0.0070 (15) | 0.0271 (15) |
C25 | 0.065 (2) | 0.068 (2) | 0.071 (2) | 0.0058 (18) | 0.0078 (17) | 0.0276 (17) |
C26 | 0.080 (3) | 0.0515 (18) | 0.0660 (19) | 0.0133 (18) | −0.0021 (18) | 0.0161 (15) |
C27 | 0.097 (3) | 0.0544 (19) | 0.071 (2) | 0.0111 (19) | 0.010 (2) | 0.0310 (17) |
C28 | 0.083 (3) | 0.0556 (19) | 0.0631 (18) | 0.0005 (18) | 0.0118 (17) | 0.0253 (16) |
C29 | 0.109 (5) | 0.141 (5) | 0.097 (3) | 0.062 (4) | 0.013 (3) | 0.040 (3) |
O1—C1 | 1.413 (4) | C22—C23 | 1.479 (5) |
O2—C2 | 1.232 (4) | C23—C28 | 1.396 (5) |
O3—C20 | 1.194 (5) | C23—C24 | 1.388 (5) |
O4—C20 | 1.318 (5) | C24—C25 | 1.382 (6) |
O4—C21 | 1.444 (7) | C25—C26 | 1.391 (6) |
O5—C22 | 1.223 (4) | C26—C27 | 1.376 (7) |
O6—C26 | 1.347 (6) | C27—C28 | 1.375 (6) |
O6—C29 | 1.409 (8) | C6—H6 | 0.9300 |
O7—C8 | 1.367 (5) | C7—H7 | 0.9303 |
O7—C11 | 1.401 (6) | C9—H9 | 0.9299 |
O1—H1 | 0.8195 | C10—H10 | 0.9305 |
N1—C4 | 1.351 (4) | C11—H11A | 0.9598 |
N1—C12 | 1.411 (4) | C11—H11B | 0.9595 |
N1—C1 | 1.488 (4) | C11—H11C | 0.9597 |
C1—C2 | 1.544 (5) | C13—H13 | 0.9294 |
C1—C19 | 1.526 (4) | C14—H14 | 0.9296 |
C2—C3 | 1.404 (4) | C15—H15 | 0.9300 |
C3—C4 | 1.396 (5) | C16—H16 | 0.9313 |
C3—C22 | 1.486 (4) | C18—H18A | 0.9608 |
C4—C5 | 1.471 (4) | C18—H18B | 0.9593 |
C5—C10 | 1.384 (5) | C18—H18C | 0.9589 |
C5—C6 | 1.411 (5) | C19—H19A | 0.9701 |
C6—C7 | 1.359 (6) | C19—H19B | 0.9695 |
C7—C8 | 1.389 (6) | C21—H21A | 0.9603 |
C8—C9 | 1.378 (6) | C21—H21B | 0.9602 |
C9—C10 | 1.401 (5) | C21—H21C | 0.9604 |
C12—C17 | 1.3901 | C24—H24 | 0.9306 |
C12—C13 | 1.3900 | C25—H25 | 0.9305 |
C13—C14 | 1.3899 | C27—H27 | 0.9299 |
C14—C15 | 1.3901 | C28—H28 | 0.9301 |
C15—C16 | 1.3901 | C29—H29A | 0.9605 |
C16—C17 | 1.3893 | C29—H29B | 0.9596 |
C17—C18 | 1.498 (18) | C29—H29C | 0.9605 |
C19—C20 | 1.494 (5) | ||
O1···O2 | 2.945 (4) | C4···H11Bvi | 2.9399 |
O1···C17 | 3.374 (6) | C9···H11C | 2.7560 |
O1···C18 | 2.977 (17) | C9···H27vii | 3.0951 |
O1···C21i | 3.240 (6) | C9···H11B | 2.7665 |
O1···O2ii | 2.681 (4) | C11···H9 | 2.5393 |
O2···C19ii | 3.282 (5) | C12···H19B | 2.7130 |
O2···O1 | 2.945 (4) | C12···H10 | 2.5756 |
O2···C23 | 3.343 (4) | C15···H21Ax | 2.8092 |
O2···C24 | 3.368 (5) | C15···H18Bxi | 3.0771 |
O2···O1ii | 2.681 (4) | C17···H10 | 2.7766 |
O3···C3 | 3.260 (5) | C18···H21Ci | 2.9138 |
O3···C24 | 3.404 (6) | C20···H21Biv | 3.0696 |
O3···C2 | 2.841 (5) | C20···H13 | 3.0153 |
O3···N1 | 3.238 (5) | C21···H15x | 3.0849 |
O3···C4 | 3.409 (5) | C22···H6 | 2.6069 |
O5···C5 | 3.407 (5) | C23···H6 | 3.0250 |
O5···C6 | 3.355 (6) | C25···H29B | 2.7795 |
O6···C6iii | 3.265 (6) | C25···H29C | 2.7201 |
O6···C7iii | 3.223 (6) | C26···H14ix | 2.9342 |
O1···H18A | 2.2424 | C28···H29Biii | 3.0934 |
O2···H1ii | 1.9831 | C29···H18Cxii | 3.0378 |
O2···H19Aii | 2.5914 | C29···H25 | 2.5260 |
O2···H1 | 2.7360 | H1···O2 | 2.7360 |
O3···H21C | 2.5596 | H1···H19A | 2.3551 |
O3···H21Biv | 2.7826 | H1···O2ii | 1.9831 |
O3···H21B | 2.6030 | H1···C2ii | 2.9067 |
O3···H11Av | 2.7702 | H1···H19Aii | 2.4464 |
O3···H24 | 2.4858 | H6···C3 | 2.7417 |
O5···H9vi | 2.5795 | H6···C22 | 2.6069 |
O5···H28 | 2.5913 | H6···C23 | 3.0250 |
O6···H6iii | 2.7930 | H6···O6iii | 2.7930 |
O6···H7iii | 2.7144 | H7···O6iii | 2.7144 |
N1···O3 | 3.238 (5) | H9···C11 | 2.5393 |
N1···H10 | 2.8112 | H9···H11B | 2.3409 |
N1···H18A | 2.5628 | H9···H11C | 2.3266 |
C1···C18 | 3.533 (17) | H9···O5vi | 2.5795 |
C2···O3 | 2.841 (5) | H10···N1 | 2.8112 |
C2···C24 | 3.302 (5) | H10···C12 | 2.5756 |
C3···O3 | 3.260 (5) | H10···C17 | 2.7766 |
C4···O3 | 3.409 (5) | H11A···O3v | 2.7702 |
C5···C9vi | 3.595 (6) | H11B···C9 | 2.7665 |
C5···C13 | 3.256 (6) | H11B···H9 | 2.3409 |
C5···O5 | 3.407 (5) | H11B···C3vi | 2.8609 |
C6···O5 | 3.355 (6) | H11B···C4vi | 2.9399 |
C6···C22 | 3.112 (5) | H11C···C9 | 2.7560 |
C6···O6iii | 3.265 (6) | H11C···H9 | 2.3266 |
C7···C7v | 3.434 (7) | H13···C4 | 2.9869 |
C7···O6iii | 3.223 (6) | H13···C20 | 3.0153 |
C9···C5vi | 3.595 (6) | H14···C26vii | 2.9342 |
C9···C10vi | 3.360 (6) | H15···C21x | 3.0849 |
C10···C13 | 3.298 (6) | H15···H21Ax | 2.1481 |
C10···C10vi | 3.439 (5) | H16···H18B | 2.5937 |
C10···C17 | 3.518 (5) | H16···H18C | 2.5686 |
C10···C9vi | 3.360 (6) | H18A···O1 | 2.2424 |
C10···C12 | 2.997 (5) | H18A···N1 | 2.5628 |
C12···C10 | 2.997 (5) | H18A···C1 | 2.9261 |
C12···C20 | 3.495 (6) | H18A···H21Ci | 2.4505 |
C13···C19 | 3.485 (7) | H18B···H16 | 2.5937 |
C13···C5 | 3.256 (6) | H18B···C15xi | 3.0771 |
C13···C20 | 3.418 (7) | H18C···C29xiii | 3.0378 |
C13···C10 | 3.298 (6) | H18C···H16 | 2.5686 |
C14···C26vii | 3.516 (8) | H19A···H1 | 2.3551 |
C14···C27vii | 3.577 (8) | H19A···O2ii | 2.5914 |
C17···O1 | 3.374 (6) | H19A···H1ii | 2.4464 |
C17···C10 | 3.518 (5) | H19B···C12 | 2.7130 |
C18···C1 | 3.533 (17) | H21A···C15x | 2.8092 |
C18···O1 | 2.977 (17) | H21A···H15x | 2.1481 |
C19···O2ii | 3.282 (5) | H21B···O3 | 2.6030 |
C19···C13 | 3.485 (7) | H21B···O3iv | 2.7826 |
C20···C12 | 3.495 (6) | H21B···C20iv | 3.0696 |
C20···C13 | 3.418 (7) | H21C···O3 | 2.5596 |
C21···O1viii | 3.240 (6) | H21C···C18viii | 2.9138 |
C22···C6 | 3.112 (5) | H21C···H18Aviii | 2.4505 |
C23···O2 | 3.343 (4) | H24···O3 | 2.4858 |
C24···O2 | 3.368 (5) | H24···C2 | 2.8022 |
C24···C2 | 3.302 (5) | H24···C3 | 2.5299 |
C24···O3 | 3.404 (6) | H25···C29 | 2.5260 |
C26···C14ix | 3.516 (8) | H25···H29B | 2.3974 |
C27···C14ix | 3.577 (8) | H25···H29C | 2.2504 |
C1···H18A | 2.9261 | H27···C9ix | 3.0951 |
C2···H24 | 2.8022 | H28···O5 | 2.5913 |
C2···H1ii | 2.9067 | H29B···C25 | 2.7795 |
C3···H24 | 2.5299 | H29B···H25 | 2.3974 |
C3···H11Bvi | 2.8609 | H29B···C28iii | 3.0934 |
C3···H6 | 2.7417 | H29C···C25 | 2.7201 |
C4···H13 | 2.9869 | H29C···H25 | 2.2504 |
C20—O4—C21 | 115.9 (4) | C25—C26—C27 | 119.8 (4) |
C26—O6—C29 | 119.2 (4) | C26—C27—C28 | 120.9 (4) |
C8—O7—C11 | 118.6 (3) | C23—C28—C27 | 120.0 (4) |
C1—O1—H1 | 109.54 | C5—C6—H6 | 120.02 |
C1—N1—C4 | 109.0 (2) | C7—C6—H6 | 119.93 |
C1—N1—C12 | 122.3 (3) | C6—C7—H7 | 119.19 |
C4—N1—C12 | 127.6 (3) | C8—C7—H7 | 119.21 |
O1—C1—C2 | 108.7 (3) | C8—C9—H9 | 120.02 |
O1—C1—C19 | 109.4 (2) | C10—C9—H9 | 119.99 |
O1—C1—N1 | 108.6 (3) | C5—C10—H10 | 119.62 |
N1—C1—C19 | 113.3 (3) | C9—C10—H10 | 119.80 |
C2—C1—C19 | 114.5 (3) | O7—C11—H11A | 109.45 |
N1—C1—C2 | 102.0 (2) | O7—C11—H11B | 109.48 |
O2—C2—C3 | 130.1 (3) | O7—C11—H11C | 109.45 |
C1—C2—C3 | 108.0 (3) | H11A—C11—H11B | 109.45 |
O2—C2—C1 | 121.6 (2) | H11A—C11—H11C | 109.47 |
C2—C3—C4 | 107.7 (3) | H11B—C11—H11C | 109.51 |
C2—C3—C22 | 124.1 (3) | C12—C13—H13 | 120.01 |
C4—C3—C22 | 127.8 (2) | C14—C13—H13 | 119.98 |
N1—C4—C3 | 113.1 (2) | C13—C14—H14 | 120.01 |
N1—C4—C5 | 121.0 (3) | C15—C14—H14 | 119.98 |
C3—C4—C5 | 125.7 (3) | C14—C15—H15 | 120.03 |
C4—C5—C10 | 123.5 (3) | C16—C15—H15 | 120.01 |
C6—C5—C10 | 118.6 (3) | C15—C16—H16 | 119.94 |
C4—C5—C6 | 117.9 (3) | C17—C16—H16 | 120.02 |
C5—C6—C7 | 120.1 (4) | C17—C18—H18A | 109.45 |
C6—C7—C8 | 121.6 (4) | C17—C18—H18B | 109.43 |
O7—C8—C7 | 116.0 (4) | C17—C18—H18C | 109.49 |
C7—C8—C9 | 119.2 (4) | H18A—C18—H18B | 109.47 |
O7—C8—C9 | 124.8 (4) | H18A—C18—H18C | 109.49 |
C8—C9—C10 | 120.0 (3) | H18B—C18—H18C | 109.51 |
C5—C10—C9 | 120.6 (3) | C1—C19—H19A | 108.54 |
N1—C12—C13 | 117.4 (4) | C1—C19—H19B | 108.59 |
N1—C12—C17 | 122.6 (4) | C20—C19—H19A | 108.49 |
C13—C12—C17 | 119.98 | C20—C19—H19B | 108.50 |
C12—C13—C14 | 120.00 | H19A—C19—H19B | 107.52 |
C13—C14—C15 | 120.01 | O4—C21—H21A | 109.42 |
C14—C15—C16 | 119.96 | O4—C21—H21B | 109.48 |
C15—C16—C17 | 120.04 | O4—C21—H21C | 109.45 |
C12—C17—C16 | 120.00 | H21A—C21—H21B | 109.53 |
C12—C17—C18 | 124.3 (8) | H21A—C21—H21C | 109.51 |
C16—C17—C18 | 115.6 (8) | H21B—C21—H21C | 109.43 |
C1—C19—C20 | 115.0 (3) | C23—C24—H24 | 119.40 |
O3—C20—O4 | 122.9 (4) | C25—C24—H24 | 119.36 |
O4—C20—C19 | 111.5 (3) | C24—C25—H25 | 120.44 |
O3—C20—C19 | 125.6 (4) | C26—C25—H25 | 120.35 |
O5—C22—C23 | 121.0 (3) | C26—C27—H27 | 119.51 |
C3—C22—C23 | 117.9 (3) | C28—C27—H27 | 119.54 |
O5—C22—C3 | 121.1 (3) | C23—C28—H28 | 119.94 |
C22—C23—C28 | 121.1 (3) | C27—C28—H28 | 120.09 |
C24—C23—C28 | 118.8 (3) | O6—C29—H29A | 109.42 |
C22—C23—C24 | 120.0 (3) | O6—C29—H29B | 109.52 |
C23—C24—C25 | 121.2 (4) | O6—C29—H29C | 109.50 |
C24—C25—C26 | 119.2 (4) | H29A—C29—H29B | 109.45 |
O6—C26—C25 | 123.7 (4) | H29A—C29—H29C | 109.46 |
O6—C26—C27 | 116.5 (4) | H29B—C29—H29C | 109.47 |
C21—O4—C20—O3 | 0.8 (7) | N1—C4—C5—C10 | 36.5 (5) |
C21—O4—C20—C19 | −177.2 (5) | C3—C4—C5—C6 | 32.5 (5) |
C29—O6—C26—C27 | −174.0 (4) | C3—C4—C5—C10 | −147.7 (4) |
C29—O6—C26—C25 | 6.2 (6) | N1—C4—C5—C6 | −143.3 (4) |
C11—O7—C8—C9 | 1.2 (6) | C6—C5—C10—C9 | 0.6 (5) |
C11—O7—C8—C7 | −179.0 (4) | C10—C5—C6—C7 | −1.6 (6) |
C12—N1—C1—C2 | 165.6 (3) | C4—C5—C6—C7 | 178.2 (4) |
C4—N1—C12—C13 | 62.2 (5) | C4—C5—C10—C9 | −179.2 (3) |
C12—N1—C4—C5 | 8.6 (5) | C5—C6—C7—C8 | 1.5 (7) |
C1—N1—C12—C17 | 79.2 (5) | C6—C7—C8—C9 | −0.3 (7) |
C1—N1—C12—C13 | −103.8 (4) | C6—C7—C8—O7 | 179.9 (4) |
C12—N1—C1—O1 | −79.7 (4) | C7—C8—C9—C10 | −0.8 (6) |
C1—N1—C4—C3 | −0.1 (4) | O7—C8—C9—C10 | 179.0 (4) |
C4—N1—C1—O1 | 111.9 (3) | C8—C9—C10—C5 | 0.6 (6) |
C12—N1—C1—C19 | 42.0 (4) | C13—C12—C17—C18 | −176.9 (8) |
C4—N1—C1—C19 | −126.3 (3) | C13—C12—C17—C16 | 0.00 |
C4—N1—C1—C2 | −2.7 (3) | N1—C12—C17—C18 | 0.0 (9) |
C4—N1—C12—C17 | −114.7 (4) | N1—C12—C13—C14 | −177.1 (5) |
C12—N1—C4—C3 | −167.7 (3) | N1—C12—C17—C16 | 176.9 (4) |
C1—N1—C4—C5 | 176.1 (3) | C17—C12—C13—C14 | −0.07 |
C19—C1—C2—O2 | −57.9 (4) | C12—C13—C14—C15 | 0.07 |
O1—C1—C2—O2 | 64.7 (4) | C13—C14—C15—C16 | 0.00 |
O1—C1—C2—C3 | −109.9 (3) | C14—C15—C16—C17 | −0.05 |
N1—C1—C2—O2 | 179.3 (3) | C15—C16—C17—C12 | 0.04 |
C19—C1—C2—C3 | 127.4 (3) | C15—C16—C17—C18 | 177.2 (8) |
C2—C1—C19—C20 | −53.3 (4) | C1—C19—C20—O4 | −160.1 (3) |
N1—C1—C2—C3 | 4.7 (4) | C1—C19—C20—O3 | 22.0 (6) |
N1—C1—C19—C20 | 63.1 (4) | C3—C22—C23—C28 | −168.0 (3) |
O1—C1—C19—C20 | −175.6 (3) | O5—C22—C23—C24 | −162.7 (3) |
O2—C2—C3—C22 | −6.4 (6) | O5—C22—C23—C28 | 11.7 (5) |
C1—C2—C3—C22 | 167.7 (3) | C3—C22—C23—C24 | 17.5 (4) |
C1—C2—C3—C4 | −4.9 (4) | C22—C23—C24—C25 | 173.6 (3) |
O2—C2—C3—C4 | −179.0 (4) | C24—C23—C28—C27 | 0.1 (5) |
C4—C3—C22—C23 | −125.4 (4) | C22—C23—C28—C27 | −174.4 (3) |
C4—C3—C22—O5 | 54.8 (5) | C28—C23—C24—C25 | −1.0 (5) |
C22—C3—C4—C5 | 15.1 (6) | C23—C24—C25—C26 | 0.0 (6) |
C2—C3—C22—O5 | −116.2 (4) | C24—C25—C26—O6 | −178.4 (4) |
C2—C3—C4—N1 | 3.3 (4) | C24—C25—C26—C27 | 1.8 (6) |
C22—C3—C4—N1 | −168.9 (3) | C25—C26—C27—C28 | −2.7 (6) |
C2—C3—C22—C23 | 63.5 (5) | O6—C26—C27—C28 | 177.5 (4) |
C2—C3—C4—C5 | −172.7 (3) | C26—C27—C28—C23 | 1.8 (6) |
Symmetry codes: (i) x−1, y, z; (ii) −x+1, −y, −z+1; (iii) −x+2, −y, −z+2; (iv) −x+2, −y, −z+1; (v) −x+2, −y+1, −z+2; (vi) −x+1, −y+1, −z+2; (vii) x, y+1, z; (viii) x+1, y, z; (ix) x, y−1, z; (x) −x+2, −y+1, −z+1; (xi) −x+1, −y+1, −z+1; (xii) x+1, y−1, z; (xiii) x−1, y+1, z. |
D—H···A | D—H | H···A | D···A | D—H···A |
O1—H1···O2ii | 0.82 | 1.98 | 2.681 (4) | 143 |
C9—H9···O5vi | 0.93 | 2.58 | 3.485 (6) | 165 |
C18—H18A···O1 | 0.96 | 2.24 | 2.977 (17) | 132 |
C18—H18A···N1 | 0.96 | 2.56 | 2.995 (17) | 107 |
C19—H19A···O2ii | 0.97 | 2.59 | 3.282 (5) | 128 |
C24—H24···O3 | 0.93 | 2.49 | 3.404 (6) | 169 |
Symmetry codes: (ii) −x+1, −y, −z+1; (vi) −x+1, −y+1, −z+2. |
Experimental details
Crystal data | |
Chemical formula | C29H27NO7 |
Mr | 501.52 |
Crystal system, space group | Triclinic, P1 |
Temperature (K) | 293 |
a, b, c (Å) | 8.948 (5), 11.254 (5), 13.724 (5) |
α, β, γ (°) | 110.167 (5), 93.755 (5), 90.106 (5) |
V (Å3) | 1294.1 (10) |
Z | 2 |
Radiation type | Mo Kα |
µ (mm−1) | 0.09 |
Crystal size (mm) | 0.28 × 0.24 × 0.18 |
Data collection | |
Diffractometer | Siemens SMART CCD area-detector diffractometer |
Absorption correction | Part of the refinement model (ΔF) (Parkin et al., 1995) Cubic fit to sin(theta)/lambda - 24 parameters |
Tmin, Tmax | 0.975, 0.984 |
No. of measured, independent and observed [I > 2σ(I)] reflections | 5384, 5384, 2742 |
Rint | 0.000 |
(sin θ/λ)max (Å−1) | 0.645 |
Refinement | |
R[F2 > 2σ(F2)], wR(F2), S | 0.078, 0.257, 1.00 |
No. of reflections | 5384 |
No. of parameters | 322 |
No. of restraints | 1 |
H-atom treatment | H atoms treated by a mixture of independent and constrained refinement |
Δρmax, Δρmin (e Å−3) | 0.54, −0.29 |
Computer programs: SMART (Siemens, 1996), SAINT (Siemens, 1996), SAINT, SIR97 (Altomare et al., 1999), SHELXL97 (Sheldrick, 1997), ORTEP-3 for Windows (Farrugia, 1997), PARST (Nardelli, 1995) and WinGX (Farrugia, 1999).
O1—C1 | 1.413 (4) | O6—C29 | 1.409 (8) |
O2—C2 | 1.232 (4) | O7—C8 | 1.367 (5) |
O3—C20 | 1.194 (5) | O7—C11 | 1.401 (6) |
O4—C20 | 1.318 (5) | N1—C4 | 1.351 (4) |
O4—C21 | 1.444 (7) | N1—C12 | 1.411 (4) |
O5—C22 | 1.223 (4) | N1—C1 | 1.488 (4) |
O6—C26 | 1.347 (6) | ||
C20—O4—C21 | 115.9 (4) | N1—C4—C3 | 113.1 (2) |
C26—O6—C29 | 119.2 (4) | N1—C4—C5 | 121.0 (3) |
C8—O7—C11 | 118.6 (3) | O7—C8—C7 | 116.0 (4) |
C1—N1—C4 | 109.0 (2) | O7—C8—C9 | 124.8 (4) |
C1—N1—C12 | 122.3 (3) | N1—C12—C13 | 117.4 (4) |
C4—N1—C12 | 127.6 (3) | N1—C12—C17 | 122.6 (4) |
O1—C1—C2 | 108.7 (3) | O3—C20—O4 | 122.9 (4) |
O1—C1—C19 | 109.4 (2) | O4—C20—C19 | 111.5 (3) |
O1—C1—N1 | 108.6 (3) | O3—C20—C19 | 125.6 (4) |
N1—C1—C19 | 113.3 (3) | O5—C22—C23 | 121.0 (3) |
N1—C1—C2 | 102.0 (2) | O5—C22—C3 | 121.1 (3) |
O2—C2—C3 | 130.1 (3) | O6—C26—C25 | 123.7 (4) |
O2—C2—C1 | 121.6 (2) | O6—C26—C27 | 116.5 (4) |
C21—O4—C20—O3 | 0.8 (7) | O1—C1—C2—O2 | 64.7 (4) |
C21—O4—C20—C19 | −177.2 (5) | O1—C1—C2—C3 | −109.9 (3) |
C4—N1—C1—O1 | 111.9 (3) |
D—H···A | D—H | H···A | D···A | D—H···A |
O1—H1···O2i | 0.82 | 1.98 | 2.681 (4) | 143 |
C9—H9···O5ii | 0.93 | 2.58 | 3.485 (6) | 165 |
C19—H19A···O2i | 0.97 | 2.59 | 3.282 (5) | 128 |
Symmetry codes: (i) −x+1, −y, −z+1; (ii) −x+1, −y+1, −z+2. |
The title compound, (I), is a derivative of 2,3-dihydro-1H-3-pyrrolone, which exhibits antimicrobiological and pharmacological activity (Koz'minykh et al., 2002). The bond lengths and angles in (I) (Table 1) are within normal ranges (Allen et al., 1987). The methoxycarbonylmethyl group shows an E conformation. Compound (I) consists of four planar rings, viz A, B, C and D (Fig. 1). In pyrrolone ring A, the maximum deviation from planarity is 0.028 (3) Å for C2. The dihedral angles between rings A/B, A/C, A/D, B/C, B/D and C/D are 34.6 (1), 72.0 (2), 74.2 (1), 59.6 (2), 80.3 (1) and 40.1 (2)°, respectively.
The crystal structure of (I) is stabilized by O—H···O and C—H···O intermolecular contacts (Table 2).