Detecting Highly Conserved Regions of the Human Genome by Multispecies Sequence Comparisons

  1. E.H. MARGULIES,
  2. NISC COMPARATIVE SEQUENCING PROGRAM, and
  3. E.D. GREEN
  1. *Genome Technology Branch and NIH Intramural Sequencing Center (NISC), National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892

This extract was created in the absence of an abstract.

Excerpt

The Human Genome Project's recent completion of ahigh-quality sequence of the human genome represents alandmark scientific accomplishment of great historic significance. It also signifies a critical transition for the fieldof genomics, as the focus now shifts from elucidating thehuman genome sequence to establishing the functionalinformation that it encodes. To capitalize on this new andpowerful informational resource as well as the ever-advancing technologies for performing genetic and genomic studies, plans for compelling and ambitious research programs have been formulated (Collins et al.2003)...

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