Initiator Met-tRNA-independent Translation Mediated by an Internal Ribosome Entry Site Element in Cricket Paralysis Virus-like Insect Viruses

  1. E. JAN,
  2. S.R. THOMPSON,
  3. J.E. WILSON,
  4. T.V. PESTOVA,
  5. C.U.T. HELLEN, and
  6. P. SARNOW
  1. *Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305; †Department of Microbiology and Immunology, Morse Institute of Molecular Genetics, State University of New York Health Sciences Center at Brooklyn, Brooklyn, New York 11203

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In eukaryotic cells, the translation of the majority ofmessenger RNAs is initiated by a scanning mechanism(Kozak 1989) whereby the 40S ribosomal subunit is recruited to the 5′-terminal end of the capped mRNA as a43S complex, consisting of the 40S ribosome, the ternaryMet-tRNAi/eIF2-GTP complex, and factors eIF1A andeIF3 (Hershey and Merrick 2000). The 43S complex thenscans the mRNA in an ATP-dependent manner until it locates an appropriate start AUG where the 60S subunitjoins to form an 80S ribosome...

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  1. doi:10.1101/sqb.2001.66.285 Cold Spring Harb Symp Quant Biol 66: 285-292

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