Cyclins and Their Partners during Xenopus Oocyte Maturation
This extract was created in the absence of an abstract.
Excerpt
Xenopus oocytes are arrested in prophase of first meiosis, which can be considered equivalent to G2 of the normal somatic cell cycle, in the sense that DNA replication is complete and the next significant cell cycle event will be nuclear envelope breakdown and formation of a spindle that will organize the distribution of condensed chromosomes to its poles. Oocytes contain a precursor of an activity, known as maturation-promoting factor (MPF), which is normally activated when the cells are exposed to progesterone (Masui and Markert 1971; Smith and Ecker 1971). Active MPF is defined as the agent that promotes the G2/M transition in stage VI oocytes, and one of its important components is the serine-threonine kinase composed of p34cdc2 and a B-type cyclin (Arion et al. 1988; Dunphy et al. 1988; Gautier et al. 1988, 1990; Lohka et al. 1988; Labbé et al. 1989). However, the MPF activity found in metaphase-arrested...
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↵Present Address: Department of Biology, Faculty of Science, Kyushu University, 6.10.1 Hakozaki, Fukuoka 812, Japan
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↵† Present Address: Swiss Cancer Research Center [ISREC], Ch. Des Bovaresses 155, CH-1066 Épalinges sur Lausanne, Switzerland
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↵‡ Present Address: Department of Physiology, School of Medicine, University of California, San Francisco, California 94143-0444
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↵§ Present Address: Ernst Boehringer Institut für Arzneimittelforschung, A-1121 Wien, Postfach 103, Dr Boehringer Gasse 5-11, Austria.
