The Putative Oncogene PRAD1 Encodes a Novel Cyclin
This extract was created in the absence of an abstract.
Excerpt
Our identification and cloning of the novel cyclin PRAD1 began with the aim of characterizing a parathyroid tumor oncogene. Parathyroid adenomas are common benign tumors that cause clinical disease not by their mass per se, but by their secretion of excessive quantities of parathyroid hormone (PTH), which in turn causes hypercalcemia. Primary hyperparathyroidism has an annual incidence of 1–2 per 1000 people and an estimated prevalence of 0.5%, can be seen at any age but is most often found after the fifth decade, and occurs more frequently in women than in men. Among patients with primary hyperparathyroidism, 80–85% have a single hypercellular parathyroid gland (adenoma), about 15% have multigland enlargement (primary hyperplasia), and less than 1% have parathyroid carcinoma. Unlike adenocarcinoma of the colon, parathyroid carcinoma does not appear to evolve from a preexisting adenoma. The etiologies of all these forms of hyperparathyroidism are unknown, although a minority of cases...
