Class I MHC-restricted Cytotoxic Responses to Soluble Protein Antigen
This extract was created in the absence of an abstract.
Excerpt
Peripheral T lymphocytes that use the α and β receptor chains to recognize foreign antigen can be classified on the basis of the type of major histocompatibility complex (MHC) molecule with which they interact. Thus, T cells recognize antigen in association with the class I glycoproteins of the MHC (H-2K, D, or L in mice), or their recognition of foreign antigen may be restricted by the MHC class II molecules (I-A and I-E in mice). This subdivision correlates perfectly with the expression by the T cell of the accessory molecules CD8 (for class I) and CD4 (for class II). There is recent, direct evidence to explain this perfect correlation, namely, that these accessory molecules on the T cell interact with the relatively conserved regions of the MHC glycoproteins on the antigen-presenting cell (Potter et al. 1989; Salter et al. 1989). It is fair to say that most class-I-restricted, CD8+T cells...
