Control of Cellular and Humoral Immune Responses by Peptides Containing T-cell Epitopes
This extract was created in the absence of an abstract.
Excerpt
T cells are known to recognize antigen in the form of peptides bound to major histocompatibility complex (MHC)-encoded class II molecules (Babbit et al. 1985; Schwartz et al. 1985; Buus et al. 1987; Guillet et al. 1987). Experiments with MHC-encoded class II molecules in planar membranes show that the binding of the T-cell receptor (TCR) to the peptide/MHC complex may not be sufficient for activation of the responding T cells (Quill and Schwartz 1987). One signal to the T cells is the binding of the TCR/CD3 complex to the antigen/MHC. As proposed by Bretscher and Cohn (1970), lymphocytes may be tolerized unless they see a second signal. This second signal for T cells can be provided in principle by the antigen-presenting cell (APC), either through the secretion of soluble cytokines or by the interaction of molecules on the APC and T-cell surface. To test this hypothesis, we exposed mice to...
