Molecular Approaches to Mammalian Genetics
This extract was created in the absence of an abstract.
Excerpt
In the last few years a number of new genetic and molecular techniques have emerged for analyzing the mammalian, and especially the human, genome. The genetic analysis has concentrated on the new possibilities of using DNA probes as genetic markers, allowing major progress on both establishing a human linkage map (Botstein et al. 1980) and identifying and using closely linked DNA markers in the genetic analysis of genes defined by mammalian (human and mouse) mutations.
However, molecular analysis, based on the availability of cloned genes, has up to now been restricted mostly to genes identified either by their gene products (e.g., globin) or by their somatically selectable function (e.g., oncogenes), a fairly small subset of the genetic information necessary (and possibly sufficient) to encode human beings (or mice).
Many of the as yet unclonable genes, which at the moment can only be defined by the effect of alleles or mutations,...
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↵* Present address: Department of Internal Medicine, Stanford University Medical Center, Stanford, California 94305.
