The mutH, mutL, mutS, and uvrD Genes of Salmonella typhimurium LT2
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Excerpt
Several genetic phenomena, including high negative interference (White and Fox 1974) and gene conversion of bacteriophage heteroduplexes (Baas and Jansz 1972; Nevers and Spatz 1975; Wildenberg and Meselson 1975; Wagner and Meselson 1976; Bauer et al. 1981) have suggested the existence of a process that converts mismatched base pairs to normal base pairs (Radding 1978; Sklar and Strauss 1980). For such a system to repair effectively mismatches arising as replication errors, it must have some way of recognizing the parental strand so that the correct base pair can be restored. The results of transfection experiments with heteroduplex λ DNAs that differ in the degree of methylation and carry different genetic markers (Radman et al. 1980; Pukkila et al. 1983) have led to the suggestion that it is the presence of N6-methyladenine in the parental strand that allows it to be discriminated from the newly synthesized (unmethylated) daughter strand. Such methylation...
