A Trans-acting Protein Kinase Identified in Cells Transformed by Abelson Murine Leukemia Virus
This extract was created in the absence of an abstract.
Excerpt
Abelson murine leukemia virus (Ab-MuLV) is a transformation-defective retrovirus derived from the Moloney murine leukemia virus (M-MuLV). The basic biology, genomic structure, mRNA species, protein translation products, and serological characterization of Ab-MuLV are reviewed elsewhere (Baltimore et al., this volume). The prototype Ab-MuLV strain is known to encode a single major polyprotein with a molecular weight (m.w.) of 120,000 (P120) and an amino-terminal region (∼30,000 m.w.) derived from retained sequences of the M-MuLV genome. A car-boxyterminal region (∼90,000 m.w.) encoded from the Ab-MuLV unique sequences contains distinctive antigenic determinants (Witte et al. 1978, 1979).
Recently, strain variants have been isolated that differ in the size of the Ab-MuLV polyprotein encoded (Rosenberg et al., this volume). All current isolates (90,000–160,000 m.w.) retain a common amino-terminal M-MuLV-derived region and a region encoding an Ab-MuLV-specific antigen; therefore, they probably differ at their carboxyl termini. All the isolates tested were phosphoproteins (Witte et al...
