Pioneering EBF2 remodels the brown fat chromatin landscape
- Department of Pathology and Laboratory Medicine and Molecular Biology Institute, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90272, USA
- Corresponding author: ptontonoz{at}mednet.ucla.edu
Abstract
In this issue of Genes & Development, Shapira and colleagues (pp. 660–673) outline mechanisms by which the brown fat transcription factor early B-cell factor 2 (EBF2) selectively activates brown lineage-specific gene expression. The investigators show that EBF2 interacts with and recruits a tissue-specific BAF chromatin remodeling complex to brown fat gene enhancers, thereby regulating chromatin accessibility. Their findings provide important insight into epigenetic regulation of adipocyte fate and thermogenic gene expression.
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.299644.117.
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