Abstract
The knowledge that brain functional connectomes are both unique and reliable has enabled behaviourally relevant inferences at a subject level. However, it is unknown whether such “fingerprints” persist under altered states of consciousness. Ayahuasca is a potent serotonergic psychedelic which elicits a widespread dysregulation of functional connectivity. Used communally in religious ceremonies, its shared use may highlight relevant novel interactions between mental state and FC inherency. Using 7T fMRI, we assessed resting-state static and dynamic FCs for 21 Santo Daime members after collective ayahuasca intake in an acute, within-subject study. Here, connectome fingerprinting revealed a shared functional space, accompanied by a spatiotemporal reallocation of keypoint edges. Importantly, we show that interindividual differences in higher-order FCs motifs are relevant to experiential phenotypes, given that they can predict perceptual drug effects. Collectively, our findings offer an example as to how individualised connectivity markers can be used to trace a subject’s functional connectome across altered states of consciousness.
Competing Interest Statement
The authors have declared no competing interest.
Footnotes
Funding EA acknowledges financial support from the SNSF Ambizione project “Fingerprinting the brain: network science to extract features of cognition, behavior and dysfunction” (grant number PZ00P2_185716).
JR acknowledges financial support from Dutch Research Council (NWO) project “A targeted imaging-metabolomics approach to classify harms of novel psychoactive substances” (grant number 406.18. GO.019).
Conflict of interest None
Updated the BioRxiv abstract. Uploaded the same Supplementary