Withdrawn
WITHDRAWN: In vivo CRISPR screen defines Slc25a37 as an organ-specific regulator of antioxidant metabolism in metastasis
View ORCID ProfileAlejandro M. Cuadros, Juan Fernández-Garcia, Mélanie Planque, Patricia Altea-Manzano, Tessa Schalley, Ines Vermeire, Dorien Broekaert, Qi Wu, Thomas Van Brussel, Sophia Leduc, Marion Maetens, Ha-Linh Nguyen, Karen Van Baelen, Naama Darzi, Giuseppe Floris, Hans Wildiers, Christine Desmedt, Diether Lambrechts, View ORCID ProfileSarah-Maria Fendt
doi: https://doi.org/10.1101/2022.09.03.506468
Alejandro M. Cuadros
1Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium
2Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium
Juan Fernández-Garcia
1Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium
2Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium
Mélanie Planque
1Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium
2Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium
Patricia Altea-Manzano
1Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium
2Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium
Tessa Schalley
1Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium
2Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium
Ines Vermeire
1Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium
2Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium
Dorien Broekaert
1Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium
2Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium
Qi Wu
3Laboratory of Experimental Oncology, Department of Oncology, Herestraat 49 - box 815 3000 Leuven, Belgium
Thomas Van Brussel
4Laboratory for Translational Genetics (VIB-KULeuven) Herestraat 49, Box 912 ON IV, 3000 Leuven Belgium
Sophia Leduc
5Laboratory for Translational Breast Cancer Research, Department of Oncology, Herestraat 49 - box 810 3000 Leuven, Belgium
Marion Maetens
5Laboratory for Translational Breast Cancer Research, Department of Oncology, Herestraat 49 - box 810 3000 Leuven, Belgium
Ha-Linh Nguyen
5Laboratory for Translational Breast Cancer Research, Department of Oncology, Herestraat 49 - box 810 3000 Leuven, Belgium
Karen Van Baelen
5Laboratory for Translational Breast Cancer Research, Department of Oncology, Herestraat 49 - box 810 3000 Leuven, Belgium
Naama Darzi
6Molecular Cell Biology Department, Weizmann Institute, 7661678 Rehovot, Israel
Giuseppe Floris
7Department of Imaging and Pathology, Laboratory of Translational Cell & Tissue Research; KU Leuven - University of Leuven, University Hospitals Leuven, Department of Pathology; 3000 Leuven, Belgium
Hans Wildiers
3Laboratory of Experimental Oncology, Department of Oncology, Herestraat 49 - box 815 3000 Leuven, Belgium
8Department of general medical oncology, Laboratory of Experimental Oncology, University Hospitals Leuven, Herestraat 49 - box 815 3000 Leuven, Belgium
Christine Desmedt
5Laboratory for Translational Breast Cancer Research, Department of Oncology, Herestraat 49 - box 810 3000 Leuven, Belgium
Diether Lambrechts
4Laboratory for Translational Genetics (VIB-KULeuven) Herestraat 49, Box 912 ON IV, 3000 Leuven Belgium
Sarah-Maria Fendt
1Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium
2Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium
Withdrawal Statement
The authors have withdrawn their manuscript owing to the detection of inaccurate data analysis in some figure panels that leads in some but not all cases to a different interpretation of the data after corrected analysis. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author.
Competing Interest Statement
S.-M.F. has received funding from Bayer AG, Merck, Alesta Therapeutics and Black Belt Therapeutics, has consulted for Fund+ and is in the advisory board of Alesta Therapeutics. A.M.C. and S.-M.F. are listed as inventors on a provisional patent application submitted by the VIB on a target identified in this work. The other authors declare no competing interests.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Posted September 11, 2023.
WITHDRAWN: In vivo CRISPR screen defines Slc25a37 as an organ-specific regulator of antioxidant metabolism in metastasis
Alejandro M. Cuadros, Juan Fernández-Garcia, Mélanie Planque, Patricia Altea-Manzano, Tessa Schalley, Ines Vermeire, Dorien Broekaert, Qi Wu, Thomas Van Brussel, Sophia Leduc, Marion Maetens, Ha-Linh Nguyen, Karen Van Baelen, Naama Darzi, Giuseppe Floris, Hans Wildiers, Christine Desmedt, Diether Lambrechts, Sarah-Maria Fendt
bioRxiv 2022.09.03.506468; doi: https://doi.org/10.1101/2022.09.03.506468
WITHDRAWN: In vivo CRISPR screen defines Slc25a37 as an organ-specific regulator of antioxidant metabolism in metastasis
Alejandro M. Cuadros, Juan Fernández-Garcia, Mélanie Planque, Patricia Altea-Manzano, Tessa Schalley, Ines Vermeire, Dorien Broekaert, Qi Wu, Thomas Van Brussel, Sophia Leduc, Marion Maetens, Ha-Linh Nguyen, Karen Van Baelen, Naama Darzi, Giuseppe Floris, Hans Wildiers, Christine Desmedt, Diether Lambrechts, Sarah-Maria Fendt
bioRxiv 2022.09.03.506468; doi: https://doi.org/10.1101/2022.09.03.506468
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