1887

Abstract

The interaction between activated bovine T lymphocytes (BTLs) and bovine herpesvirus type 1 (BHV-1) was investigated. BHV-1 infection of BTLs reduced the amplitude of recombinant bovine interleukin 2-induced proliferative responses. This decreased proliferation was caused by a virus-induced lymphocytolysis which was dependent on viable virus and was not inhibited by recombinant bovine interferon-α1. Furthermore, lymphocytolysis was not associated with virus replication or with the synthesis of detectable levels of viral proteins. Electron microscopic examination of virus-infected cells revealed that lymphocytolysis was characterized by early nuclear disintegration resembling apoptosis. These observations suggest that activated T cells, localized at the site of BHV-1 infection, may be susceptible to virus-induced cytolysis.

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1990-02-01
2024-04-24
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References

  1. Allan E. M., Mosolla P. M. 1980; Scanning electron microscopy of the tracheal epithelium of calves inoculated with bovine herpesvirus 1. Research in Veterinary Science 29:325–327
    [Google Scholar]
  2. Allan E. M., Pirie H. M., Mosolla P. M., Selman I. E., Wiseman A. 1980; The pathological features of severe cases of infectious bovine rhinotracheitis. Veterinary Record 107:441–444
    [Google Scholar]
  3. Babiuk L. A., Bielefeldt Ohmann H., Gifford G., Czarniecki C. W., Scialli V. T., Hamilton E. B. 1985; Effect of bovine a! interferon on bovine herpesvirus type 1-induced respiratory disease. Journal of General Virology 66:2383–2394
    [Google Scholar]
  4. Baker P. E. 1987; Bovine interleukin 2: cloning, high level expression, and purification. Veterinary Immunology and Immuno-pathology 17:193–209
    [Google Scholar]
  5. Baker P. E., Knoblock K. F. 1982; Bovine costimulator. II. Generation and maintenance of a bovine costimulator-dependent bovine lymphoblastoid cell line. Veterinary Immunology and Immuno-pathology 3:381–397
    [Google Scholar]
  6. Bielefeldt Ohmann H., Babiuk L. A. 1985; Viral-bacterial pneumonia in calves: effect of bovine herpesvirus-1 on immunologic functions. Journal of Infectious Diseases 151:937–947
    [Google Scholar]
  7. Bielefeldt Ohmann H., Babiuk L. A. 1986; Alteration of alveolar macrophage functions after aerosol infection with bovine herpesvirus type-1. Infection and Immunity 51:344–347
    [Google Scholar]
  8. Bielefeldt Ohmann H., Bloch B. 1982; Electron microscopic studies of bovine viral diarrhoea virus in tissues of diseased calves and in cell cultures. Archives of Virology 71:57–74
    [Google Scholar]
  9. Bielefeldt Ohmann H., Gilchrist J. E., Babiuk L. A. 1984; Effect of recombinant DNA-produced bovine interferon alpha (BoIFN-α1) on the interaction between bovine alveolar macrophages and bovine herpesvirus type 1. Journal of General Virology 65:1487–1495
    [Google Scholar]
  10. Carter J., Magnuson N. S., Davis W. C., Mason P. H., Magnuson J. A., Talmadge J. E., Barr P. J. 1986; Development and maintenance of bovine cytotoxic lymphocytes with recombinant human interleukin-2. Immunology 57:123–132
    [Google Scholar]
  11. Davis W. C., Marusic S., Lewin H. A., Splitter G. A., Perryman L. E., McGuire T. C., Gorman J. R. 1987; The development and analysis of species-specific and cross-reactive monoclonal antibodies to leukocyte differentiation antigens and antigens of the major histocompatability complex for use in the study of the immune system in cattle and other species. Veterinary Immunology and Immunopathology 15:337–376
    [Google Scholar]
  12. Fenwick M. L., Clark J. 1982; Early and delayed shut-off of host protein synthesis in cells infected with herpes simplex virus. Journal of General Virology 61:121–125
    [Google Scholar]
  13. Filion L. G., McGuire R. L., Babiuk L. A. 1983; Non-specific suppressive effect of bovine herpesvirus type 1 on bovine leukocyte functions. Infection and Immunity 42:106–112
    [Google Scholar]
  14. Forman A. J., Babiuk L. A. 1982; Effect of infectious bovine rhinotracheitis virus infection on bovine alveolar macrophage function. Infection and Immunity 35:1041–1047
    [Google Scholar]
  15. Forman A. J., Babiuk L. A., Misra V., Baldwin F. 1982; Susceptibility of bovine macrophages to infectious bovine rhinotracheitis virus infection. Infection and Immunity 35:1048–1057
    [Google Scholar]
  16. Fulton R. W., Root S. K. 1978; Antiviral activity in interferon- treated tracheal organ cultures. Infection and Immunity 21:672–673
    [Google Scholar]
  17. Gibbs E. P. J., Rweyemamu M. M. 1977; Bovine herpesviruses. Part I. Veterinary Bulletin 47:317–343
    [Google Scholar]
  18. Griebel P. J., Qualtiere L., Davis W. C., Gee A., Bielefeldt Ohmann H., Lawman M. J. P., Babiuk L. A. 1988; T lymphocyte population dynamics and function following a primary bovine herpesvirus type-1 infection. Viral Immunology 1:287–304
    [Google Scholar]
  19. Hammer S. M., Gillis J. M. 1985; Herpes simplex virus replication in interleukin-2-stimulated human T cells. Journal of Infectious Diseases 151:544–548
    [Google Scholar]
  20. Hammer S. M., Carney W. P., Iacoviello V. R., Lowe B. R., Hirsch M. S. 1982; Herpes simplex virus infection of human T-cell subpopulations. Infection and Immunity 38:795–797
    [Google Scholar]
  21. Jericho K. W. F., Le Q.Darcel C. 1978; Response of the respiratory tract of calves kept at controlled climatic conditions to bovine herpesvirus 1 in aerosol. Canadian Journal of Comparative Medicine 42:156–167
    [Google Scholar]
  22. Kwong A. D., Kruper J. A., Frenkel N. 1988; Herpes simplex virus virion host shutoff function. Journal of Virology 62:912–921
    [Google Scholar]
  23. Laemmli U. K. 1970; Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature; London: 227680–685
    [Google Scholar]
  24. Lawman M. J. P., Griebel P., Hutchings D. L., Davis W. C., Heise J., Qualtiere L., Babiuk L. A. 1988; Generation of IL-2- dependent bovine cytotoxic T lymphocyte clones reactive against BHV-1 infected target cells: loss of genetic restriction and virus specificity. Viral Immunology 1:163–176
    [Google Scholar]
  25. Mechor G. D., Rousseaux C. G., Radostits O. M., Babiuk L. A., Petrie L. 1987; Protection of newborn calves against fatal multisystemic infectious bovine rhinotracheitis by feeding colostrum from vaccinated cows. Canadian Journal of of Veterinary Research 51:452–459
    [Google Scholar]
  26. Mintz L., Drew W. L., Hoo R., Finley T. N. 1980; Age- dependent resistance of human alveolar macrophages to herpes simplex virus. Infection and Immunity 28:417–420
    [Google Scholar]
  27. Misra V., Blumenthal R. M., Babiuk L. A. 1981; Proteins specified by bovine herpesvirus 1 (infectious bovine rhinotracheitis virus). Journal of Virology 40:367–378
    [Google Scholar]
  28. Mittnacht S., Straub P., Kirchner H., Jacobsen H. 1988; Interferon treatment inhibits onset of herpes simplex virus immediate-early transcription. Virology 164:201–210
    [Google Scholar]
  29. Nash A. A., Jayasuriya A., Phelan J., Cobbold S. P., Waldmann H., Prospero T. 1987; Different roles for L3T4+ and Lyt2+ T cell subsets in the control of an acute herpes simplex virus infection of the skin and nervous system. Journal of General Virology 68:825–833
    [Google Scholar]
  30. Nyaga P. N., McKercher D. G. 1980; Pathogenesis of bovine herpesvirus-1 (BHV-1) infections: interactions of the virus with peripheral blood components. Comparative Immunology, Microbiology and Infectious Disease 2:587–602
    [Google Scholar]
  31. Pelton B. K., Duncan I. B., Denman A. M. 1980; Herpes simplex virus depresses antibody production by affecting T-cell function. Nature; London: 284176–177
    [Google Scholar]
  32. Peter C. P., Gratzek J. B., Ramsey F. K. 1966; Isolation and characterization of a strain of infectious bovine rhinotracheitis virus associated with enteritis in cattle: pathogenesis studies by fluorescent antibody tracing. American Journal of Veterinary Research 27:1583–1590
    [Google Scholar]
  33. Plaeger-Marshall S., Smith J. W. 1978a; Experimental infection of subpopulations of human peripheral blood leukocytes by herpes simplex virus. Proceedings of the Society for Experimental Biology and Medicine 158:263–268
    [Google Scholar]
  34. Plaeger-Marshall S., Smith J. W. 1978b; Inhibition of mitogen- and antigen-induced lymphocyte blastogenesis by herpes simplex virus. Journal of Infectious Diseases 138:506–511
    [Google Scholar]
  35. Price V., Mochizuki D., March C. J., Cosman D., Deeley M. C., Klinke R., Clevenger W., Gillis S., Baker P., Urdal D. 1987; Expression, purification and characterization of the recombinant murine granulocyte-macrophage colony-stimulating factor and bovine interleukin-2 from yeast. Gene 55:287–293
    [Google Scholar]
  36. Purifoy D. J. M., Powell K. I. 1976; DNA binding proteins induced by herpes simplex type 2 in Hep 2 cells. Journal of Virology 19:717–731
    [Google Scholar]
  37. Rouse B. T., Babiuk L. A. 1974; Host defence mechanisms against infectious bovine rhinotracheitis virus: in vitro stimulation of sensitized lymphocytes by virus antigen. Infection and Immunity 10:681–687
    [Google Scholar]
  38. Rouse B. T., Babiuk L. A. 1975; Host defence mechanisms against infectious bovine rhinotracheitis virus II. Inhibition of viral plaque formation by immune peripheral blood lymphocytes. Cellular Immunology 17:43–56
    [Google Scholar]
  39. Schmidd D. S. 1988; The human MHC-restricted cellular response to herpes simplex virus type 1 is mediated by CD4+, CD8 T cells and is restricted to the DR region of the MHC complex. Journal of Immunology 140:3610–3616
    [Google Scholar]
  40. Splitter G. A., Eskra L. 1986; Bovine T lymphocyte response to bovine herpesvirus-1: cell phenotypes, viral recognition and acid- labile interferon production. Veterinary Immunology and Immuno- pathology 11:235–250
    [Google Scholar]
  41. Wyllie A. H. 1981; Cell death: a new classification separating apoptosis from necrosis. In Cell Death in Biology and Pathology pp. 9–34 Bowar I. D., Lockshin R. A. Edited by New York: Chapman and Hall;
    [Google Scholar]
  42. Wyllie A. H., Kerr J. F. R., Currie A. R. 1980; Cell death: the significance of apoptosis. International Review of Cytology 68:251–306
    [Google Scholar]
  43. Yates W. D. G. 1982; A review of infectious bovine rhinotracheitis, shipping fever pneumonia and viral-bacterial synergism in respiratory disease of cattle. Canadian Journal of Comparative Medicine 46:225–263
    [Google Scholar]
  44. Yates W. D. G., Babiuk L. A., Jericho K. W. F. 1983; Viral- bacterial pneumonia in calves: duration of the interaction between bovine herpesvirus 1 and Pasteurella haemolytica. Canadian Journal of Comparative Medicine 47:257–264
    [Google Scholar]
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