1887

Abstract

SUMMARY

Infection of LS cells with HSV-1 resulted in an inhibition of spermidine and spermine synthesis from putrescine, possibly through inhibition of host cell protein synthesis. The rate of putrescine uptake increased soon after infection, and later, polyamines were lost from the cells. Inhibition of spermidine and spermine synthesis by methylglyoxal bis(amidinohydrazone) did not affect virus replication.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-27-1-25
1975-04-01
2024-04-20
Loading full text...

Full text loading...

/deliver/fulltext/jgv/27/1/JV0270010025.html?itemId=/content/journal/jgv/10.1099/0022-1317-27-1-25&mimeType=html&fmt=ahah

References

  1. Bachrach U., Dion S., Wiener W. 1974; Occurrence of polyamines in myxoviruses. Journal of General Virology 22:451–454
    [Google Scholar]
  2. Bell D. 1974; The effect of canavanine on herpes simplex virus replication. Journal of General Virology 22:319–330
    [Google Scholar]
  3. Caldarera C. M., Moruzzi M. S., Barriroli B., Moruzzi G. 1968; Spermine and spermidine of the prostate gland of orchiectomized rats and their effect on RNA polymerase activity. Biochemical and Biophysical Research Communications 33:266–271
    [Google Scholar]
  4. Cohen S. S. 1971 Introduction to the Polyamines137 New Jersey: Prentice-Hall;
    [Google Scholar]
  5. Gibson W., Roizman B. 1971; Compartmentalisation of spermine and spermidine in the herpes simplex virion. Proceedings of the National Academy of Sciences of the United States of America 68:2818–2821
    [Google Scholar]
  6. Grollman A. P. 1966; Structural basis of protein synthesis inhibition by emetine and cycloheximide based on an analogy between ipecac alkaloids and glutarimide antibiotics. Proceedings of the National A cademy of Sciences of the United States of America 56:1867–1874
    [Google Scholar]
  7. Hershko A., Mamont P., Shields R., Tomkins G. M. 1971; “Pleiotypic control”. Nature New Biology 232:206–211
    [Google Scholar]
  8. Kamiya T., Ben-Porat T., Kaplan A. S. 1965; Control of certain aspects of the infective process by progeny viral DNA. Virology 26:577–589
    [Google Scholar]
  9. Pegg A. E. 1970; Biosynthesis of putrescine and polyamines in mammalian tissues. Annals of the New York Academy of Sciences 171:977–987
    [Google Scholar]
  10. Pohjanpelto P., Raina A. 1972b; Identification of growth factor produced by human fibroblasts in vitro as putrescine. Nature New Biology 235:247–249
    [Google Scholar]
  11. Quash G., Gresland L., Delain E., Huppert J. 1972; Antipolyamine antibodies and cell lysis. Experimental Cell Research 75:363–368
    [Google Scholar]
  12. Roizman B. 1969 Biochemistry of Viruses415 Edited by Levy J. New York: Marcel-Dekker;
    [Google Scholar]
  13. Seiler N., Wiechmann M. 1967; Die microbestimmung von spermin und spermidin als i-dimethylamino-naphthalene-5-sulfonsaure-derivate. Zeischrift fur Physiologische Chemie 348:1285–1290
    [Google Scholar]
  14. Williams-Ashman H. G., Schenone A. 1972; Methylglyoxal bis(amidinohydrazone) as a potent inhibitor of mammalian and yeast S-adenosyl methionine decarboxylases. Biochemical and Biophysical Research Communications 46:288–295
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-27-1-25
Loading
/content/journal/jgv/10.1099/0022-1317-27-1-25
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error